{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:08:28Z","timestamp":1791922108584,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2001,9,28]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Abstract\u2014<\/jats:italic>\n            <\/jats:bold>\n            We have shown that exposure of pregnant ewes to dexamethasone (11.5 mg\/d for 2 days) at 27 days of gestation (term, 150 days) led to increased blood pressure and cardiac output in adult offspring. In this study, we hypothesized that dexamethasone-induced hypertension is associated with left ventricular hypertrophy and a reduced cardiac functional reserve (CO\n            <jats:sub>max-0<\/jats:sub>\n            ). Six control animals (group C) and five dexamethasone-exposed animals (group D) were volume-loaded with Hemaccel until the wedge pressure was 13 mm Hg (baseline). The wedge pressure was held constant during an infusion of dobutamine at incremental doses (0.4 to 12 \u03bcg\/kg\/min) while blood pressure and cardiac output were measured. The same protocol was repeated in each animal 5 days later under mild general anesthesia (1.5% isoflurane), when transthoracic echocardiography (M-mode) was obtained. Group D showed a reduced CO\n            <jats:sub>max-0<\/jats:sub>\n            in response to dobutamine during both conscious (89\u00b122 versus 150\u00b125 mL\/kg\/min in control;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01) and anesthetized states (91\u00b138 versus 156\u00b156 mL\/kg\/min in control;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). Reduced CO\n            <jats:sub>max-0<\/jats:sub>\n            in group D was associated with higher left ventricular mass index compared with group C (2.6\u00b10.67 versus 1.8\u00b10.51 g\/kg;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). In addition, group D showed a reduced cardiac contractility reserve (FS\n            <jats:sub>max-0<\/jats:sub>\n            ) in response to dobutamine (21\u00b122% versus 54\u00b134% in group C;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). An impaired cardiac functional reserve in group D was associated with increased left ventricular type I collagen content. In conclusion, brief prenatal exposure to dexamethasone led to the development of hypertension, left ventricular hypertrophy, and reduced cardiac functional reserve in adult life.\n          <\/jats:p>","DOI":"10.1161\/hh1901.097086","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:32:49Z","timestamp":1191004369000},"page":"623-629","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["Impaired Cardiac Functional Reserve and Left Ventricular Hypertrophy in Adult Sheep After Prenatal Dexamethasone Exposure"],"prefix":"10.1161","volume":"89","author":[{"given":"Miodrag","family":"Dodic","sequence":"first","affiliation":[{"name":"From the Howard Florey Institute (M.D., C.S., K.M., E.M.W.), University of Melbourne and Department of Cardiology (J.M., L.G., J.W.), Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrishan","family":"Samuel","sequence":"additional","affiliation":[{"name":"From the Howard Florey Institute (M.D., C.S., K.M., E.M.W.), University of Melbourne and Department of Cardiology (J.M., L.G., J.W.), Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Moritz","sequence":"additional","affiliation":[{"name":"From the Howard Florey Institute (M.D., C.S., K.M., E.M.W.), University of Melbourne and Department of Cardiology (J.M., L.G., J.W.), Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Howard Florey Institute (M.D., C.S., K.M., E.M.W.), University of Melbourne and Department of Cardiology (J.M., L.G., J.W.), Royal Melbourne Hospital, Parkville, Melbourne, Victoria, 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