{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:30:35Z","timestamp":1791048635805,"version":"4.1.0"},"reference-count":80,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2001,9,28]]},"abstract":"<jats:p>In recent years, there has been a sustained interest in vascularization processes. Much, if not all, of the work has included the concept of new vessel morphogenesis. Surprisingly, most of the work has not addressed developmental mechanisms directly, but rather as an offshoot of a disease process, wound healing process, or from the perspective of inducing vessels in an ischemic site. One theme has dominated the various studies on capillary or endothelial tube morphogenesis\u2014integrin-mediated cell behavior. Integrin biology impacts virtually every known step of nascent vessel formation. In this review article, we attempted to summarize key findings from the viewpoint of developmental biologists\/morphologists. We also attempted to summarize and contrast data obtained using integrin gene ablation approaches in mice with other experimental systems. It is hoped this review will provide a distinct cell biological perspective to vascular scientists from the clinical, molecular, and tissue engineering communities.<\/jats:p>","DOI":"10.1161\/hh1901.097747","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:32:49Z","timestamp":1191004369000},"page":"566-572","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Integrins in Vascular Development"],"prefix":"10.1161","volume":"89","author":[{"given":"Paul A.","family":"Rupp","sequence":"first","affiliation":[{"name":"From the Department of Anatomy and Cell Biology (P.A.R., C.D.L.), and the Vascular Biology Center (C.D.L.), University of Kansas Medical Center, Kansas City, Kans."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Little","sequence":"additional","affiliation":[{"name":"From the Department of Anatomy and Cell Biology (P.A.R., C.D.L.), and the Vascular Biology Center (C.D.L.), University of Kansas Medical Center, Kansas City, Kans."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.4.1097"},{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Drake CJ Little CD. The morphogenesis of primordial vascular networks. In: Little CD Mironov V Sage EH eds: Vascular Morphogenesis: In Vivo In Vitro In Mente. Boston Mass: Birkhauser; 1998: 3\u201321.","DOI":"10.1007\/978-1-4612-4156-0_2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10115.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1087>3.0.CO;2-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/386671a0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092280107"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1996.0009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1996.1989"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/380435a0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/380439a0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/376066a0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/376062a0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1079"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8443"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1093"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0195-27"},{"key":"e_1_3_3_17_2","first-page":"1279","volume":"141","year":"1992","unstructured":"Strieter RM, Kunkel SL, Elner VM, Martonyi CL, Koch AE, Polverini PJ, Elner SG. Interleukin-8: a corneal factor that induces neovascularization. Am J Pathol. 1992; 141: 1279\u20131284.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117857"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90115-S"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13612"},{"key":"e_1_3_3_21_2","first-page":"293","volume":"149","year":"1996","unstructured":"Senger DR, Ledbetter SR, Claffey KP, Papadopoulos-Sergiou A, Peruzzi CA, Detmar M. Stimulation of endothelial cell migration by vascular permeability factor\/vascular endothelial growth factor through cooperative mechanisms involving the \u03b1v\u03b23 integrin, osteopontin, and thrombin. Am J Pathol. 1996; 149: 293\u2013305.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_22_2","first-page":"851","volume":"6","year":"2000","unstructured":"Byzova TV, Goldman CK, Pampori N, Thomas KA, Bett A, Shattil SJ, Plow EF. A mechanism for modulation of cellular responses to VEGF: activation of the integrins. Mol Cell. 2000; 6: 851\u2013860.","journal-title":"Mol Cell"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12394617"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.26794"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4644(20000915)78:4<674::AID-JCB16>3.0.CO;2-G"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.31189"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.15069"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00117-4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2000.2265"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.2.699"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/15419069609014219"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.7.11.1737"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9451"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.132.1.227"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0109"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65038-9"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001446200"},{"key":"e_1_3_3_38_2","first-page":"S91","volume":"100","year":"1997","unstructured":"Shattil SJ, Ginsberg MH. Integrin signaling in vascular biology. J Clin Invest. 1997; 100: S91\u2013S95.","journal-title":"J Clin Invest"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5430.1028"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.4.469"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.4.882"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007040200"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.10.3463"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.22.3979"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.22.6622"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.5.1255"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118808"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.4.1083"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.46.29380"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003668200"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81618-9"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.2.549"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5487"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.15.1883"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.15.1896"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90514-2"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.1852"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5241.1500"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7512751"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90007-8"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118227"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81235-0"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80931-9"},{"key":"e_1_3_3_64_2","first-page":"119","volume":"98","year":"2001","unstructured":"Silletti S, Kessler T, Goldberg J, Boger DL, Cheresh DA. Disruption of matrix metalloproteinase 2 binding to integrin \u03b1v\u03b23 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proc Natl Acad Sci USA. 2001; 98: 119\u2013124.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0596-529"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9764"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3756"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.108.7.2655"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001930111"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65005-5"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.2.497"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.13.1423"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.9.2885"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.11.8051"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000186200"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81848-6"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1024"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.16.11101"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90320-9"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90092-H"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hh1901.097747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T02:16:44Z","timestamp":1715653004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hh1901.097747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,28]]},"references-count":80,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,9,28]]}},"alternative-id":["10.1161\/hh1901.097747"],"URL":"https:\/\/doi.org\/10.1161\/hh1901.097747","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,28]]},"assertion":[{"value":"2001-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}