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Preexisting veins of all sizes, including a branch of the main artery, are subjected to segmentation. Loop formation and segmentation are based on intussusceptive microvascular growth. Loop formation is followed by elongation. Loop remodeling occurs also by intussusception and results in the formation of compound loop systems. All loop systems observed were completely patent. Blind-ending sprouts were extremely rare. Anastomoses between the preexisting vessels subjected to segmentation and the loop systems were established to include the newly formed vessels into the preexisting vascular network. The formation of an increasing number of patent loop systems likely decreases hypoxia and subsequently arrests angiogenesis with transformation of the granulation tissue into a scar. Loop formation also occurred inside a large thrombus that occluded a part of the lumen of the main vein.<\/jats:p>","DOI":"10.1161\/hh2001.097870","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:32:49Z","timestamp":1191004369000},"page":"723-731","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Vascular Morphogenesis and Remodeling in a Model of Tissue Repair"],"prefix":"10.1161","volume":"89","author":[{"given":"Sybill","family":"Patan","sequence":"first","affiliation":[{"name":"From the Departments of Radiation Oncology (S.P., L.L.M., S.T., S.R., R.K.J.) and Anesthesia (R.C.J.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance L.","family":"Munn","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology (S.P., L.L.M., S.T., S.R., R.K.J.) and Anesthesia (R.C.J.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Tanda","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology (S.P., L.L.M., S.T., S.R., R.K.J.) and Anesthesia (R.C.J.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Roberge","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology (S.P., L.L.M., S.T., S.R., R.K.J.) and Anesthesia (R.C.J.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh K.","family":"Jain","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology (S.P., L.L.M., S.T., S.R., R.K.J.) and Anesthesia (R.C.J.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary C.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology (S.P., L.L.M., S.T., S.R., R.K.J.) and Anesthesia (R.C.J.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1950.0014"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092160207"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092280107"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.55.Suppl_65"},{"key":"e_1_3_3_5_2","first-page":"121","volume":"187","year":"1993","unstructured":"Patan S, Haenni B, Burri PH. 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