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Here, we show that dynamic platelet shape changes occurring during distinct phases of the adhesive process are precisely regulated by \u201cinside-out\u201d and \u201coutside-in\u201d integrin signals and are also a key regulatory element in successful platelet thrombogenesis opposing rapid blood flow in vivo.<\/jats:p>","DOI":"10.1161\/hq0202.104122","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:16:47Z","timestamp":1027898207000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":93,"title":["Platelet Shape Changes and Adhesion Under High Shear Flow"],"prefix":"10.1161","volume":"22","author":[{"given":"Mitsuhiro","family":"Kuwahara","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Matsui","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Mizuno","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Miyata","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","first-page":"265","volume":"14","year":"1977","unstructured":"Sixma JJ, Wester J. 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