{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:14:00Z","timestamp":1780514040157,"version":"3.54.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["ATVB"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>\n            The effects of dietary intervention, sex, and apolipoprotein E phenotype on tracking of serum lipid values in young children have remained poorly characterized. We investigated these associations in 1062 infants who were randomized into control and intervention groups (n=522 and n=540, respectively) at age 7 months; the intervention group received counseling aimed at maintaining a low-saturated fat, low-cholesterol diet. In 519 children in the control (n=254) and intervention (n=265) groups, serum lipid values were studied annually between 13 months and 5 years of age. In all children, tracking was strongest for the ratio of high density lipoprotein (HDL) cholesterol to total cholesterol; when a 13-month-old child belonged to the lowest quartile of the distribution, the odds ratio for belonging to the same quartile at older ages was 39.0 (95% CI 23.1 to 66.0). Dietary intervention did not influence the tracking of serum lipids. Tracking of HDL cholesterol was stronger in the boys than in the girls (\n            <jats:italic>P<\/jats:italic>\n            =0.018). Tracking of non-HDL cholesterol and apolipoprotein B in the children with phenotypes E2\/3 or E3\/3 was stronger than that in the other children (\n            <jats:italic>P<\/jats:italic>\n            =0.031 and\n            <jats:italic>P<\/jats:italic>\n            =0.014, respectively). In conclusion, the apolipoprotein E phenotype strongly influences tracking of non-HDL cholesterol and apolipoprotein B values in early childhood, whereas dietary intervention had no effect on tracking of any of the lipids. A child\u2019s sex influenced tracking only of HDL cholesterol, with boys showing stronger tracking.\n          <\/jats:p>","DOI":"10.1161\/hq0302.104516","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:16:47Z","timestamp":1027898207000},"page":"492-498","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of Dietary Intervention, Sex, and Apolipoprotein E Phenotype on Tracking of Serum Lipids and Apolipoproteins in 1- to 5-Year-Old Children"],"prefix":"10.1161","volume":"22","author":[{"given":"Leena","family":"Rask-Nissila\u0308","sequence":"first","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Viikari","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tammi","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"Ro\u0308nnemaa","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Marniemi","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Salo","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Routi","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; the Department of Pediatrics (E.J.), University of Helsinki, Helsinki, Finland; and the Research and Development Centre of Social Insurance Institution (J.M.), Turku, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Helenius","sequence":"additional","affiliation":[{"name":"From the Research Centre of Applied and Preventive Cardiovascular Medicine (L.R.-N., A.T., P.S., T.R.) and the Departments of Pediatrics (L.R.-N., A.T., P.S., T.R., I.V., O.S.), Medicine (J.V., T.R.), and Biostatistics (H.H.), University of Turku, Turku, Finland; 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