{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:16:32Z","timestamp":1790741792623,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background and Purpose<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            The purpose of this study was to prospectively evaluate the effects of body position in patients with large supratentorial stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            We performed 43 monitoring sessions in 18 patients with acute complete or subtotal middle cerebral artery (MCA) territory stroke. Intracranial pressure (ICP) was monitored with a parenchymal probe. Mean arterial blood pressure, ICP, and MCA peak mean flow velocity (V\n            <jats:sub>m<\/jats:sub>\n            MCA) were continuously recorded. Patients with acute ICP crises were excluded. After baseline values at a 0\u00b0 supine position were attained, the backrest was elevated in 2 steps of 5 minutes each to 15\u00b0 and 30\u00b0 and then returned to 0\u00b0.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Results<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Baseline mean arterial pressure was 90.0\u00b11.6 mm Hg and fell to 82.7\u00b11.7 mm Hg at 15\u00b0 and 76.1\u00b11.6 mm Hg at 30\u00b0 backrest elevation (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). ICP decreased from 13.0\u00b10.9 to 12.0\u00b10.9 mm Hg at 15\u00b0 and 11.4\u00b10.9 mm Hg at 30\u00b0 backrest elevation (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). As a result, cerebral perfusion pressure decreased from a baseline value of 77.0\u00b11.8 to 70.0\u00b11.8 mm Hg at 15\u00b0 and 64.7\u00b11.7 mm Hg at 30\u00b0 backrest elevation (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). V\n            <jats:sub>m<\/jats:sub>\n            MCA was already higher on the affected side during baseline measurements. V\n            <jats:sub>m<\/jats:sub>\n            MCA decreased from 72.8\u00b111.3 cm\/s at 0\u00b0 to 67.2\u00b19.7 cm\/s at 15\u00b0 and 61.2\u00b18.9 cm\/s at 30\u00b0 on the affected and from 49.9\u00b13.7 cm\/s at 0\u00b0 to 47.7\u00b13.6 cm\/s at 15\u00b0 and 46.2\u00b12.2 cm\/s at 30\u00b0 on the contralateral side (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            In patients with large hemispheric stroke without an acute ICP crisis, cerebral perfusion pressure was maximal in the horizontal position although ICP was usually at its highest point. If adequate cerebral perfusion pressure is considered more desirable than the absolute level of ICP, the horizontal position is optimal for these patients.\n          <\/jats:p>","DOI":"10.1161\/hs0202.102376","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:16:47Z","timestamp":1027898207000},"page":"497-501","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":175,"title":["Effects of Body Position on Intracranial Pressure and Cerebral Perfusion in Patients With Large Hemispheric Stroke"],"prefix":"10.1161","volume":"33","author":[{"given":"Stefan","family":"Schwarz","sequence":"first","affiliation":[{"name":"From the Departments of Neurology and Neurosurgery (A.A.), University of Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Georgiadis","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology and Neurosurgery (A.A.), University of Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Aschoff","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology and Neurosurgery (A.A.), University of Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology and Neurosurgery (A.A.), University of Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","first-page":"107","volume":"59","year":"1993","unstructured":"Schneider GH, von Helden GH, Franke R, Lanksch WR, Unterberg A. 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