{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:59:53Z","timestamp":1774893593034,"version":"3.50.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background and Purpose<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Current transcranial Doppler criteria for vasospasm after aneurysmal subarachnoid hemorrhage are not age specific. We analyzed the effect of age on cerebral blood flow velocity changes after subarachnoid hemorrhage and constructed an age-adjusted predictive model of cerebral blood flow velocity in subarachnoid hemorrhage patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            We identified patients with aneurysmal subarachnoid hemorrhage admitted between 1991 and 1999 with a prospective transcranial Doppler database. Eighty-one patients, with complete medical records and transcranial Doppler examinations of the vessels of interest, were included. Patients were subdivided into 2 groups by age: younger, &lt;68 years of age (n=47) and older, \u226568 years of age (n=34). Maximum mean flow velocity and incidence of symptomatic vasospasm were reported. Linear and nonlinear regression analyses were performed.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Results<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Middle cerebral artery and internal carotid artery mean flow velocity were lower in older patients (median 76 versus 114 cm\/s and 76 versus 126 cm\/s, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.003). Incidence of symptomatic vasospasm was lower in older patients (44% versus 66%;\n            <jats:italic>P<\/jats:italic>\n            =0.05). Older patients developed symptomatic vasospasm at lower middle cerebral artery (median 57 versus 103 cm\/s;\n            <jats:italic>P<\/jats:italic>\n            =0.04) and internal carotid artery (median 54 versus 81 cm\/s,\n            <jats:italic>P<\/jats:italic>\n            =0.02) mean flow velocity. Relationship between middle cerebral artery and internal carotid artery mean flow velocity and age was quadratic (ANOVA,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Older patients have a lower incidence of symptomatic vasospasm, and such vasospasm develops at lower cerebral blood flow velocity than younger patients. A quadratic relationship was found between age and cerebral blood flow velocity. This model could be used to create an age-adjusted nomogram that might improve diagnostic capabilities of transcranial Doppler.\n          <\/jats:p>","DOI":"10.1161\/hs0901.094622","type":"journal-article","created":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T17:36:31Z","timestamp":1192037791000},"page":"2005-2011","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["Effect of Age on Cerebral Blood Flow Velocity and Incidence of Vasospasm After Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.1161","volume":"32","author":[{"given":"Michel T.","family":"Torbey","sequence":"first","affiliation":[{"name":"From the Neurosciences Critical Care Division (M.T.T., T.-K.H., A.B., M.A.W., J.A.U., M.A.M., A.Y.R.), Johns Hopkins University, School of Medicine, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till-Karsten","family":"Hauser","sequence":"additional","affiliation":[{"name":"From the Neurosciences Critical Care Division (M.T.T., T.-K.H., A.B., M.A.W., J.A.U., M.A.M., A.Y.R.), Johns Hopkins University, School of Medicine, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"From the Neurosciences Critical Care Division (M.T.T., T.-K.H., A.B., M.A.W., J.A.U., M.A.M., A.Y.R.), Johns Hopkins University, School of Medicine, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Williams","sequence":"additional","affiliation":[{"name":"From the Neurosciences Critical Care Division (M.T.T., T.-K.H., A.B., M.A.W., J.A.U., M.A.M., A.Y.R.), Johns Hopkins University, School of Medicine, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Ulatowski","sequence":"additional","affiliation":[{"name":"From the Neurosciences Critical Care Division (M.T.T., T.-K.H., A.B., M.A.W., J.A.U., M.A.M., A.Y.R.), Johns Hopkins University, School of Medicine, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek A.","family":"Mirski","sequence":"additional","affiliation":[{"name":"From the Neurosciences Critical Care Division (M.T.T., T.-K.H., A.B., M.A.W., J.A.U., M.A.M., A.Y.R.), Johns Hopkins University, School of Medicine, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y.","family":"Razumovsky","sequence":"additional","affiliation":[{"name":"From the Neurosciences Critical Care Division (M.T.T., T.-K.H., A.B., M.A.W., J.A.U., M.A.M., A.Y.R.), Johns Hopkins University, School of Medicine, Baltimore, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon19966287"},{"key":"e_1_3_3_3_2","first-page":"1237","volume":"44","year":"1999","unstructured":"Vora YY, Suarez-Almazor M, Steinke DE, Martin ML, Findlay JM. 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