{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:29:30Z","timestamp":1791307770973,"version":"4.3.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>\n                        <jats:bold>\n                          <jats:italic>Background and Purpose<\/jats:italic>\n                        <\/jats:bold>\n                        \u2014\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    The purpose of the present study was to assess the incidence and clinical significance of the intraparenchymal hyperdense areas on the posttherapeutic CT scan just after intra-arterial reperfusion therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>\n                        <jats:bold>\n                          <jats:italic>Methods<\/jats:italic>\n                        <\/jats:bold>\n                        \u2014\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    Seventy-seven patients with acute middle cerebral artery occlusion were studied prospectively with post-therapeutic CT. Hyperdense areas were classified into three groups: those in the lentiform nucleus, insular cortex and cerebral cortex. We investigated the incidence of hyperdense areas and hemorrhagic transformations and assessed whether location of hyperdense areas may play a role in the incidence of hemorrhagic transformations. We also evaluated correlation between early CT signs and hyperdense areas.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>\n                        <jats:bold>\n                          <jats:italic>Results<\/jats:italic>\n                        <\/jats:bold>\n                        \u2014\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    Forty-five hyperdense areas were seen in 37 of the 77 patients (48.1%): 19 of the 45 (42.2%) were confirmed to be hematomas themselves, 6 (13.4%) showed later conversion to petechial hemorrhages, and 20 (44.4%) showed rapid disappearance without hemorrhagic transformations. Eleven of the 37 patients (29.7%) had neurological worsening due to massive hematoma (symptomatic hemorrhage), whereas none of the 40 patients without hyperdense areas had symptomatic hemorrhage. The incidence of hemorrhage among hyperdense areas was significantly lower in the insular cortex than in the other 2 regions (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). On the other hand, hyperdense areas in the lentiform nucleus had a significantly higher incidence of neurological worsening (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). There was a significant correlation between early CT signs and hyperdense areas (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>\n                        <jats:bold>\n                          <jats:italic>Conclusions<\/jats:italic>\n                        <\/jats:bold>\n                        \u2014\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    The presence of hyperdense areas was a significant risk factor for severe hemorrhagic transformations, although only 29.7% of patients with hyperdense areas had symptomatic hemorrhage. On the contrary, the absence of hyperdense areas was a reliable negative predictor for symptomatic hemorrhage.\n                  <\/jats:p>","DOI":"10.1161\/hs0901.095602","type":"journal-article","created":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T13:36:31Z","timestamp":1192023391000},"page":"2042-2048","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["Parenchymal Hyperdensity on Computed Tomography After Intra-Arterial Reperfusion Therapy for Acute Middle Cerebral Artery Occlusion"],"prefix":"10.1161","volume":"32","author":[{"given":"Shinichi","family":"Nakano","sequence":"first","affiliation":[{"name":"From the Departments of Neurosurgery, Miyazaki Medical College (S.N., T. Iseda, S.W.) and Junwakai Memorial Hospital (H.K., Y.Y., T. Ikeda), Miyazaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Iseda","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery, Miyazaki Medical College (S.N., T. Iseda, S.W.) and Junwakai Memorial Hospital (H.K., Y.Y., T. Ikeda), Miyazaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kawano","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery, Miyazaki Medical College (S.N., T. Iseda, S.W.) and Junwakai Memorial Hospital (H.K., Y.Y., T. Ikeda), Miyazaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery, Miyazaki Medical College (S.N., T. Iseda, S.W.) and Junwakai Memorial Hospital (H.K., Y.Y., T. Ikeda), Miyazaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokuro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery, Miyazaki Medical College (S.N., T. Iseda, S.W.) and Junwakai Memorial Hospital (H.K., Y.Y., T. Ikeda), Miyazaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Wakisaka","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery, Miyazaki Medical College (S.N., T. Iseda, S.W.) and Junwakai Memorial Hospital (H.K., Y.Y., T. Ikeda), Miyazaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","first-page":"487","volume":"15","year":"1994","unstructured":"Wildenhain SL, Jungreis CA, Barr J, Mathis J, Wechsler L, Horton JA. CT after intracranial intraarterial thrombolysis for acute stroke. AJNR Am J Neuroradiol. 1994; 15: 487\u2013492.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200006000-00005"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(93)90013-Q"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.2.3515635"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199612000-00006"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.5.957"},{"key":"e_1_3_1_7_2","first-page":"767","volume":"19","year":"1998","unstructured":"Nakano S, Yokogami K, Ohta H, Yano T, Ohnishi T. Direct percutaneous transluminal angioplasty for acute middle cerebral artery occlusion. AJNR Am J Neuroradiol. 1998; 19: 767\u2013772.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_8_2","first-page":"853","volume":"46","year":"2000","unstructured":"Nakano S, Iseda T, Yoneyama T, Ikeda T, Wakisaka S. Intravenous low-dose native tissue plasminogen activator for distal embolism in the middle cerebral artery divisions or branches: a pilot study. Neurosurgery. 2000; 46: 853\u2013859.","journal-title":"Neurosurgery"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393665"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.176.3.2389039"},{"key":"e_1_3_1_11_2","first-page":"654","volume":"22","year":"2001","unstructured":"Nakano S, Iseda T, Kawano H, Yoneyama T, Ikeda T, Wakisaka S. Correlation of early CT signs in the deep middle cerebral artery territories and angiographically confirmed site of arterial occlusion. AJNR Am J Neuroradiol. 2001; 22: 654\u2013659.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.30.11.2280"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130023023"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92049-8"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607183350301"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.11.2109"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.30.7.1326"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.1.1"},{"key":"e_1_3_1_21_2","first-page":"1215","volume":"10","year":"1989","unstructured":"Bozzao L, Bastianello S, Fantozzi LM, Angeloni U, Argentino C, Fieschi C. Correlation of angiographic and sequential CT findings in patients with evolving cerebral infarction. AJNR Am J Neuroradiol. 1989; 10: 1215\u20131222.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_22_2","first-page":"9","volume":"15","year":"1994","unstructured":"von Kummer R, Meyding-Lamade U, Forsting M, Rosin L, Rieke K, Hacke W, Sartor K. Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk. AJNR Am J Neuroradiol. 1994; 15: 9\u201315.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.341"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.366"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.205.2.9356608"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.205.2.9356611"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.10.5.505496"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hs0901.095602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T22:19:16Z","timestamp":1715638756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hs0901.095602"}},"subtitle":["Incidence and Clinical Significance"],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1161\/hs0901.095602"],"URL":"https:\/\/doi.org\/10.1161\/hs0901.095602","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"2000-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}