{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:45:02Z","timestamp":1774788302745,"version":"3.50.1"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background and Purpose<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            We sought to determine pedigree availability for a concordant sibling pair study of genetic risk factors in ischemic stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Probands with confirmed ischemic stroke were prospectively enrolled. Family histories were obtained by systematic interview. A study neurologist prospectively assigned stroke subtype.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Results<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Of 310 probands (median age, 75 years; range, 26 to 97 years; 48% women), 75% had at least 1 living sibling; 10%, at least 1 concordant living sibling; 2%, at least 1 concordant sibling living in the same city; and 7%, at least 1 concordant living and 1 discordant living sibling. Likelihood of having a concordant sibling increased significantly with proband age, even after adjustment for sibship size (\n            <jats:italic>P<\/jats:italic>\n            =0.002). Positive family history of stroke was not related to either proband stroke subtype or risk factor profile.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Approximately 10 probands were screened to find 1 potentially concordant living sibling. A concordant sibling pair study should be multicentered and enable enrollment of siblings from diverse geographic areas.\n          <\/jats:p>","DOI":"10.1161\/hs1201.099795","type":"journal-article","created":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T17:48:04Z","timestamp":1192038484000},"page":"2939-2941","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Feasibility of an Affected Sibling Pair Study in Ischemic Stroke"],"prefix":"10.1161","volume":"32","author":[{"given":"James F.","family":"Meschia","sequence":"first","affiliation":[{"name":"From the Department of Neurology (J.F.M., T.G.B.) and Section of Pharmacology (J.H.), Mayo Clinic, Jacksonville, Fla, and the Department of Neurology (R.D.B.) and Section of Biostatistics (E.J.A., P.C.O\u2019B.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Robert D.","family":"Brown","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.F.M., T.G.B.) and Section of Pharmacology (J.H.), Mayo Clinic, Jacksonville, Fla, and the Department of Neurology (R.D.B.) and Section of Biostatistics (E.J.A., P.C.O\u2019B.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Brott","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.F.M., T.G.B.) and Section of Pharmacology (J.H.), Mayo Clinic, Jacksonville, Fla, and the Department of Neurology (R.D.B.) and Section of Biostatistics (E.J.A., P.C.O\u2019B.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.F.M., T.G.B.) and Section of Pharmacology (J.H.), Mayo Clinic, Jacksonville, Fla, and the Department of Neurology (R.D.B.) and Section of Biostatistics (E.J.A., P.C.O\u2019B.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.F.M., T.G.B.) and Section of Pharmacology (J.H.), Mayo Clinic, Jacksonville, Fla, and the Department of Neurology (R.D.B.) and Section of Biostatistics (E.J.A., P.C.O\u2019B.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.F.M., T.G.B.) and Section of Pharmacology (J.H.), Mayo Clinic, Jacksonville, Fla, and the Department of Neurology (R.D.B.) and Section of Biostatistics (E.J.A., P.C.O\u2019B.), Mayo Clinic, Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.2.237"},{"key":"e_1_3_2_2_2","first-page":"541","volume":"54","year":"1976","unstructured":"Hatano S. Experience from a multicentre stroke register: a preliminary report. Bull World Health Organ. 1976; 54: 541\u2013553.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/jscd.2000.20363"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hs1201.099795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T02:19:39Z","timestamp":1715653179000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hs1201.099795"}},"subtitle":["Results of a 2-Center Family History Registry"],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":4,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1161\/hs1201.099795"],"URL":"https:\/\/doi.org\/10.1161\/hs1201.099795","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]},"assertion":[{"value":"2001-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}