{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:34:40Z","timestamp":1762864480763},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>\n            To investigate whether endothelin-A receptors and nitric oxide modulate renal hemodynamics in man under angiotensin II receptor-1 blockade, 6 healthy volunteers, on a 240 mmol Na diet, underwent 4 separate renal hemodynamic measurements, in 3 of which endothelin-A blocker BQ-123 0.2 nmol \u00b7 kg \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            was infused for 90 minutes after pretreatment with either placebo, telmisartan 1 mg \u00b7 kg \u00b7 day\n            <jats:sup>\u22121<\/jats:sup>\n            for 3 days, or telmisartan as well, but with co-infusion of both BQ-123 and N\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methylester 0.5 \u03bcg \u00b7 kg \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            . A fourth infusion was made with N\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methylester alone. No change followed infusion of either N\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methylester alone or BQ-123 alone. With BQ-123 after telmisartan, renal blood flow rose from 916\u00b156 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 1.73 m\n            <jats:sup>2<\/jats:sup>\n            to 1047\u00b151.2 (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), and renal vascular resistances fell from 89\u00b17 mm Hg \u00b7 min \u00b7 L\n            <jats:sup>\u22121<\/jats:sup>\n            to 74\u00b14 (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). These changes were fully abolished by the co-infused N\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methylester. Infusion of BQ-123, devoid of renal hemodynamic effects at baseline, produces significant renal vasodilation when angiotensin II receptors are blocked, indicating an increasing renal hemodynamic role of endothelin-A\u2013receptor activity. Because such a vasodilation is prevented by nonvasoconstricting microdoses of N\n            <jats:sup>G<\/jats:sup>\n            -nitro-\n            <jats:sc>l<\/jats:sc>\n            -arginine methylester, nitric oxide\u2013endothelin balance controls substantially renal hemodynamics under angiotensin II blockade. These findings are consistent with a rationale of the association of endothelin-A blockers with angiotensin II blockers or angiotensin-converting enzyme inhibitors in treating nitric oxide\u2013deficient conditions such as arterial hypertension, heart failure, and chronic renal diseases.\n          <\/jats:p>","DOI":"10.1161\/hy0202.104399","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:16:47Z","timestamp":1027898207000},"page":"715-720","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Renal Hemodynamic Control by Endothelin and Nitric Oxide Under Angiotensin II Blockade in Man"],"prefix":"10.1161","volume":"39","author":[{"given":"Alberto","family":"Montanari","sequence":"first","affiliation":[{"name":"From the Dipartimento di Scienze Cliniche e Sperimentale, University of Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Carra","sequence":"additional","affiliation":[{"name":"From the Dipartimento di Scienze Cliniche e Sperimentale, University of Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Perinotto","sequence":"additional","affiliation":[{"name":"From the Dipartimento di Scienze Cliniche e Sperimentale, University of Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Iori","sequence":"additional","affiliation":[{"name":"From the Dipartimento di Scienze Cliniche e Sperimentale, University of Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Fasoli","sequence":"additional","affiliation":[{"name":"From the Dipartimento di Scienze Cliniche e Sperimentale, University of Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almerina","family":"Biggi","sequence":"additional","affiliation":[{"name":"From the Dipartimento di Scienze Cliniche e Sperimentale, University of Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almerico","family":"Novarini","sequence":"additional","affiliation":[{"name":"From the Dipartimento di Scienze Cliniche e Sperimentale, University of Parma, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.2.425"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.851"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816080-00001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.276.3.F417"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.34.6.1254"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V8132"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1181498"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701923"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.38.1.105"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.30.1.29"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.20.3.292"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.31.1.10"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.29.1.435"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)77807-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91667-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.35.1.518"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.2.753"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.8.752"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2000.tb00397.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09423-9"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02074-X"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00023.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01210-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1281706"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.3.C870"},{"key":"e_1_3_2_26_2","unstructured":"Epstein M. 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