{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:04:11Z","timestamp":1791374651724,"version":"4.3.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p>\n            We recently showed that brain mineralocorticoid receptors (MRs) are involved in blood pressure and kidney function control in normotensive Wistar rats. We now assessed the involvement of brain MRs in spontaneously hypertensive rats (SHR), in which the presence of adrenocorticoids has been shown to be required for the development of hypertension. The effect of a single intracerebroventricular (ICV) injection of an MR antagonist (RU28318) on systolic blood pressure (SBP) and renal function was examined in conscious adult SHR and Wistar-Kyoto rats (WKY) maintained on a standard-sodium diet (0.4% Na\n            <jats:sup>+<\/jats:sup>\n            ). In WKY, a long-lasting decrease in SBP was caused by the ICV injection of 10 ng RU28318 as previously reported in Wistar rats, associated with increased urinary excretion of water and electrolytes. In SHR maintained on the standard diet, the ICV injection of RU28318 (10 or 100 ng) had no effect on cardiovascular and renal functions. However, the ICV injection of 10 ng RU28318 in SHR after 3 weeks of high sodium intake (8% Na\n            <jats:sup>+<\/jats:sup>\n            ) caused a long-lasting decrease in SBP. The effect was present at 8 hours (\u0394SBP 34\u00b12 mm Hg), persisted at 24 hours (\u0394SBP 29\u00b11 mm Hg), and disappeared at 48 hours after the injection. The hypotension was not associated with changes in heart rate, urinary excretion of water and electrolytes, and plasma renin activity, whereas renal denervation did not affect the decrease in SBP. A more pronounced decrease in SBP (49\u00b13 mm Hg at 8 hours) was observed with 100 ng RU28318. This dose of the antagonist was without effect after subcutaneous administration. Thus, brain MRs appear to participate in the maintenance of hypertension in conscious adult SHR sensitized by sodium loading.\n          <\/jats:p>","DOI":"10.1161\/hy1001.091781","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:37:17Z","timestamp":1191004637000},"page":"902-906","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Involvement of Brain Mineralocorticoid Receptor in Salt-Enhanced Hypertension in Spontaneously Hypertensive Rats"],"prefix":"10.1161","volume":"38","author":[{"given":"Kamal","family":"Rahmouni","sequence":"first","affiliation":[{"name":"From the Institut de Pharmacologie, Faculte\u0301 de Me\u0301decine, Universite\u0301 Louis Pasteur (K.R., M.B., M.G., J.-L.I., W. De J.), Strasbourg, France; and Service d\u2019Hypertension Arte\u0301rielle, Maladies Vasculaires et Pharmacologie Clinique, Ho\u0302pitaux Universitaires de Strasbourg (M.G., J.-L.I.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette","family":"Barthelmebs","sequence":"additional","affiliation":[{"name":"From the Institut de Pharmacologie, Faculte\u0301 de Me\u0301decine, Universite\u0301 Louis Pasteur (K.R., M.B., M.G., J.-L.I., W. De J.), Strasbourg, France; and Service d\u2019Hypertension Arte\u0301rielle, Maladies Vasculaires et Pharmacologie Clinique, Ho\u0302pitaux Universitaires de Strasbourg (M.G., J.-L.I.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u0300le","family":"Grima","sequence":"additional","affiliation":[{"name":"From the Institut de Pharmacologie, Faculte\u0301 de Me\u0301decine, Universite\u0301 Louis Pasteur (K.R., M.B., M.G., J.-L.I., W. De J.), Strasbourg, France; and Service d\u2019Hypertension Arte\u0301rielle, Maladies Vasculaires et Pharmacologie Clinique, Ho\u0302pitaux Universitaires de Strasbourg (M.G., J.-L.I.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Imbs","sequence":"additional","affiliation":[{"name":"From the Institut de Pharmacologie, Faculte\u0301 de Me\u0301decine, Universite\u0301 Louis Pasteur (K.R., M.B., M.G., J.-L.I., W. De J.), Strasbourg, France; and Service d\u2019Hypertension Arte\u0301rielle, Maladies Vasculaires et Pharmacologie Clinique, Ho\u0302pitaux Universitaires de Strasbourg (M.G., J.-L.I.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wybren","family":"De Jong","sequence":"additional","affiliation":[{"name":"From the Institut de Pharmacologie, Faculte\u0301 de Me\u0301decine, Universite\u0301 Louis Pasteur (K.R., M.B., M.G., J.-L.I., W. De J.), Strasbourg, France; and Service d\u2019Hypertension Arte\u0301rielle, Maladies Vasculaires et Pharmacologie Clinique, Ho\u0302pitaux Universitaires de Strasbourg (M.G., J.-L.I.), France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/4.4.374"},{"key":"e_1_3_2_2_2","first-page":"R1025","volume":"259","year":"1990","unstructured":"Janiak PC, Lewis SJ, Brody MJ. Role of central mineralocorticoid binding sites in development of hypertension. Am J Physiol. 1990; 259: R1025\u2013R1034.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-1-118"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.5.1201"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.1.E96"},{"key":"e_1_3_2_6_2","first-page":"133","volume":"218","year":"1992","unstructured":"Van Den Berg DTWM, De Kloet ER, Janssen BJA. Central steroid receptor function in spontaneously hypertensive rats: effects of gluco- and mineralocorticoids. Genet Hypertens. 1992; 218: 133\u2013135.","journal-title":"Genet Hypertens"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.38.6.21"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1984.tb00133.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1982.62.2.347"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.35.1.126"},{"key":"e_1_3_2_11_2","first-page":"R943","volume":"265","year":"1993","unstructured":"Uyehara CFT, Gellai M. Impairment of renal function precedes establishment of hypertension in spontaneously hypertensive rats. Am J Physiol. 1993; 265: R943\u2013R950.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109966"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.1.75"},{"key":"e_1_3_2_14_2","first-page":"641","volume":"10","year":"1996","unstructured":"Rettig R, Bandelow N, Patschan O, Kuttler B, Frey B, Uber A. The importance of the kidney in primary hypertension: insights from cross-transplantation. J Hum Hypertens. 1996; 10: 641\u2013644.","journal-title":"J Hum Hypertens"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1986.tb07806.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1979.4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.7.3.357"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.70.2.1735140"},{"key":"e_1_3_2_19_2","first-page":"R21","volume":"260","year":"1991","unstructured":"Sato Y, Ando K, Ogata E, Fujita T. High-potassium diet attenuates salt-induced acceleration of hypertension in SHR. Am J Physiol. 1991; 260: R21\u2013R26.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-109-6-1841"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1050417"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.3.E482"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000126973"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8229"},{"key":"e_1_3_2_25_2","first-page":"I-2","volume":"43","year":"1978","unstructured":"Brody MJ, Fink JD, Buggy J, Haywood JR, Gordon FJ, Johnson AK. The role of the anteroventral ventricle (AV3V) region in experimental hypertension. Circ Res. 1978; 43 (suppl I): I-2\u2013I-13.","journal-title":"Circ Res"},{"key":"e_1_3_2_26_2","unstructured":"Johnson AK. Role of the periventricular tissue surrounding the anteroventral third ventricle (AV3V) in the regulation of body fluid homeostasis.In: Schrier RW ed. Vasopressin. New York NY: Raven Press; 1985: 319\u2013331."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.4.3.387"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","unstructured":"Brody MJ Faber JE Mangiapane ML Porter JP. The central nervous system and prevention of hypertension.In: De Jong W ed.: Handbook of Hypertension: Volume 4: Experimental and Genetic Models of Hypertension. New York NY: Elsevier Science; 1984: 474\u2013494.","DOI":"10.1161\/01.HYP.6.4.494"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hy1001.091781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T02:23:54Z","timestamp":1715653434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hy1001.091781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1161\/hy1001.091781"],"URL":"https:\/\/doi.org\/10.1161\/hy1001.091781","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10]]},"assertion":[{"value":"2000-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}