{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:29:11Z","timestamp":1784773751592,"version":"3.55.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n            Preeclampsia is a pregnancy specific disorder and a risk factor for later cardiovascular disease. The cause and detailed pathophysiology remains unknown. G protein signaling is involved in a variety of physiological processes, including blood pressure regulation. We assessed whether distributions of 3 single nucleotide polymorphisms in genes coding for components of G protein signaling pathways that have been associated with hypertension differ between women with preeclampsia and normotensive pregnant women; the G protein \u03b23 subunit gene (\n            <jats:italic>GNB3<\/jats:italic>\n            ) C825T polymorphism (rs5443), the angiotensin II type 1 receptor gene (\n            <jats:italic>AGTR1<\/jats:italic>\n            ) 3\u2032UTR A1166C polymorphism (rs5186), and the regulator of G protein signaling 2 gene (\n            <jats:italic>RGS2<\/jats:italic>\n            ) 3\u2032UTR C1114G polymorphism (rs4606). Two separate Norwegian study populations were used; a large population based study and a smaller, but clinically well-described pregnancy biobank. A descriptive study of 43 women with eclampsia was additionally included. In the population-based study, an increased odds of preeclampsia (odds ratio, 1.21; [95% confidence interval, 1.05\u20131.40];\n            <jats:italic>P<\/jats:italic>\n            =0.009) and recurrent preeclampsia (odds ratio, 1.43; [95% confidence interval, 1.06\u20131.92];,\n            <jats:italic>P<\/jats:italic>\n            =0.017) was found in women carrying the rs4606 CG or GG genotype. In early-onset preeclamptic patients with decidual spiral artery biopsies available (n=24), the rs4606 CG or GG genotype was more frequent in those with acute atherosis (resembling early stage of atherosclerosis) compared with those without: odds ratio, 15.0; (95% confidence interval, 2.02\u2013111.2);\n            <jats:italic>P<\/jats:italic>\n            =0.004. No association was found between preeclampsia and the rs5443 or the rs5186. The genotype distribution in eclamptic women was not different from preeclamptic women. In conclusion,\n            <jats:italic>RGS2<\/jats:italic>\n            rs4606 may affect the risk and progression of preeclampsia.\n          <\/jats:p>","DOI":"10.1161\/hypertensionaha.111.00331","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T02:47:40Z","timestamp":1358822860000},"page":"655-661","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Single Nucleotide Polymorphisms in G Protein Signaling Pathway Genes in Preeclampsia"],"prefix":"10.1161","volume":"61","author":[{"given":"Anne Stine","family":"Kvehaugen","sequence":"first","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Melien","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oddgeir Lingaas","family":"Holmen","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannele","family":"Laivuori","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"\u00d8ian","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Beathe","family":"Andersgaard","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Dechend","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Cathrine","family":"Staff","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval and Faculty of Medicine, University of Oslo, Norway (A.C.S., A.S.K.); The Norwegian Directorate of Health (\u00d8.M.), HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway (O.L.H.); Haartman Institute, Medical Genetics and Research Programs Unit, Women\u2019s Health, University of Helsinki, Finland (H.L.); Department of Clinical..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"67","article-title":"ACOG practice bulletin. 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