{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:25:37Z","timestamp":1781767537275,"version":"3.54.5"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n            Obesity and excessive lipolysis are implicated in preeclampsia (PE). Intrauterine growth restriction is associated with low maternal body mass index and decreased lipolysis. Our aim was to assess how maternal and offspring fatty acid metabolism is altered in mothers in the third trimester of pregnancy with PE (n=62) or intrauterine growth restriction (n=23) compared with healthy pregnancies (n=164). Markers of lipid metabolism and erythrocyte fatty acid concentrations were measured. Maternal adipose tissue fatty acid composition and mRNA expression of adipose tissue fatty acid\u2013metabolizing enzymes and placental fatty acid transporters were compared. Mothers with PE had higher plasma triglyceride (21%,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and nonesterified fatty acid (50%,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) concentrations than controls. Concentrations of major n\u22126 and n\u22123 long-chain polyunsaturated fatty acids in erythrocytes were 23% to 60% lower (all\n            <jats:italic>P<\/jats:italic>\n            &lt;0.005) in PE and intrauterine growth restriction mothers and offspring compared with controls. Subcutaneous adipose tissue \u0394\u22125 and \u0394\u22126 desaturase and very long-chain fatty acid elongase mRNA expression was lower in PE than controls (respectively, mean [SD] control 3.38 [2.96] versus PE 1.83 [1.91],\n            <jats:italic>P<\/jats:italic>\n            =0.030; 3.33 [2.25] versus 1.03 [0.96],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001; 0.40 [0.81] versus 0.00 [0.00],\n            <jats:italic>P<\/jats:italic>\n            =0.038 expression relative to control gene [square root]). Low maternal and fetal long-chain polyunsaturated fatty acid concentrations in PE may be the result of decreased maternal synthesis.\n          <\/jats:p>","DOI":"10.1161\/hypertensionaha.112.197897","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T01:02:53Z","timestamp":1346806973000},"page":"1078-1085","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Preeclampsia Is Associated With Compromised Maternal Synthesis of Long-Chain Polyunsaturated Fatty Acids, Leading to Offspring Deficiency"],"prefix":"10.1161","volume":"60","author":[{"given":"Vanessa A.","family":"Mackay","sequence":"first","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzya S.","family":"Huda","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Stewart","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahmeng","family":"Tham","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise A.","family":"McKenna","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Martin","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Jordan","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Ann","family":"Brown","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Hodson","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Greer","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Meyer","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilys J.","family":"Freeman","sequence":"additional","affiliation":[{"name":"From the School of Medicine (V.A.M., S.S.H., F.M.S., K.T., L.A.M., I.M., I.A.G.), Institute of Cardiovascular and Medical Sciences (F.J., E.A.B., D.J.F.), University of Glasgow, Glasgow, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom (L.H.); and School of Health Sciences, Metabolic Research Centre, University of Wollongong, Wollongong, New South Wales, Australia (B.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09827.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090640"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.033"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00825.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200411000-00021"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200211000-00023"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930859"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80023-X"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090292"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.3.925S"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.307S"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19950106"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3282f795e6"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-006-3005-5"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2217\/17584299.4.1.91"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.098608"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30040-7"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.4.853"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.40.24711"},{"key":"e_1_3_4_21_2","volume-title":"Manual of Laboratory Operations","author":"Lipid Research Clinics Program","year":"1974","unstructured":"Lipid Research Clinics Program. 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