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PA cases and EH controls were individually matched for sex, age (\u00b12 years), and office systolic blood pressure (\u00b110 mm\u2009Hg). Patients with PA and EH differed significantly in duration of hypertension, serum potassium, plasma aldosterone and plasma renin concentrations, aldosterone-to-renin ratio, and urinary aldosterone concentration (P&lt;0.001 for all comparisons). The prevalence of electrocardiographic and echocardiographic left ventricular hypertrophy was about twice higher in patients with PA even after adjustment for hypertension duration. PA patients also had a significantly higher prevalence of coronary artery disease (adjusted odds ratio, 1.9), nonfatal myocardial infarction (adjusted odds ratio, 2.6), heart failure (adjusted odds ratio, 2.9), and atrial fibrillation (adjusted odds ratio, 5.0). The risks associated with PA were similar across levels of serum potassium and plasma aldosterone. To conclude, patients with PA are more likely to have had a cardiovascular complication at diagnosis than otherwise similar patients with EH. Target organ damage and complications disproportionate to blood pressure should be considered as an additional argument for suspecting PA in a given individual and possibly for broadening the scope of screening at the population level.<\/jats:p>","DOI":"10.1161\/hypertensionaha.113.01060","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T01:18:01Z","timestamp":1370913481000},"page":"331-336","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":458,"title":["Cardiovascular Complications Associated With Primary Aldosteronism"],"prefix":"10.1161","volume":"62","author":[{"given":"S\u00e9bastien","family":"Savard","sequence":"first","affiliation":[{"name":"From the Assistance Publique-H\u00f4pitaux de Paris, Georges-Pompidou European Hospital, Hypertension Unit, Paris, France (S.S., L.A., P.-F.P.); Universit\u00e9 Paris-Descartes, Faculty of Medicine, Paris, France (L.A., P.-F.P.); Assistance Publique-H\u00f4pitaux de Paris, Tenon Hospital, Department of Internal Medicine, Paris, France (O.S.); and Universit\u00e9 Pierre et Marie Curie-Paris 6, Faculty of Medicine, Paris, France (O.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Amar","sequence":"additional","affiliation":[{"name":"From the Assistance Publique-H\u00f4pitaux de Paris, Georges-Pompidou European Hospital, Hypertension Unit, Paris, France (S.S., L.A., P.-F.P.); Universit\u00e9 Paris-Descartes, Faculty of Medicine, Paris, France (L.A., P.-F.P.); Assistance Publique-H\u00f4pitaux de Paris, Tenon Hospital, Department of Internal Medicine, Paris, France (O.S.); and Universit\u00e9 Pierre et Marie Curie-Paris 6, Faculty of Medicine, Paris, France (O.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Plouin","sequence":"additional","affiliation":[{"name":"From the Assistance Publique-H\u00f4pitaux de Paris, Georges-Pompidou European Hospital, Hypertension Unit, Paris, France (S.S., L.A., P.-F.P.); Universit\u00e9 Paris-Descartes, Faculty of Medicine, Paris, France (L.A., P.-F.P.); Assistance Publique-H\u00f4pitaux de Paris, Tenon Hospital, Department of Internal Medicine, Paris, France (O.S.); and Universit\u00e9 Pierre et Marie Curie-Paris 6, Faculty of Medicine, Paris, France (O.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Steichen","sequence":"additional","affiliation":[{"name":"From the Assistance Publique-H\u00f4pitaux de Paris, Georges-Pompidou European Hospital, Hypertension Unit, Paris, France (S.S., L.A., P.-F.P.); Universit\u00e9 Paris-Descartes, Faculty of Medicine, Paris, France (L.A., P.-F.P.); Assistance Publique-H\u00f4pitaux de Paris, Tenon Hospital, Department of Internal Medicine, Paris, France (O.S.); and Universit\u00e9 Pierre et Marie Curie-Paris 6, Faculty of Medicine, Paris, France (O.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295438"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.02.010"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291318"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.015"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.108.122002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/3.2.156"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283060f0c"},{"key":"e_1_3_3_9_2","first-page":"1425","volume-title":"Oxford Textbook of Clinical Nephrology","author":"Plouin PF","year":"1997","unstructured":"Plouin PF, Corvol P, Guyene TT. 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