{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:06:37Z","timestamp":1769241997006,"version":"3.49.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n            Antihypertensive treatment can improve tissue Doppler indices of left ventricular diastolic function in the short term, but little is known about the longer-term effect of different antihypertensive treatments on progression of left ventricular diastolic function and left ventricular hypertrophy. We hypothesized that long-term treatment of hypertension will lead to improvements in left ventricular hypertrophy and diastolic function. We collected detailed cardiovascular phenotypic data on 1006 participants from a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial. Patients randomized to either an amlodipine\u00b1perindopril-based or an atenolol\u00b1bendroflumethiazide-based regimen underwent conventional and tissue Doppler echocardiography at time of control of blood pressure after randomization (\u22481.5 years; phase 1) and after a further 2 years of antihypertensive treatment (phase 2). There were no prerandomization data. Five hundred thirty-six patients had complete data collection at both phases. Left ventricular mass index regressed from phase 1 to 2 with no significant difference between treatment groups (amlodipine: 119.5\u2013116.8; atenolol: 122.9\u2013117.5;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001 for both). Conversely, tissue Doppler diastolic indices did not change in the amlodipine\u00b1perindopril-based regimen (E\/e\u2032, 7.5\u20137.6 cm\/s;\n            <jats:italic>P<\/jats:italic>\n            =not significant), but deteriorated in the atenolol\u00b1bendroflumethiazide-based regimen (E\/e\u2032, 8.0\u20138.5 cm\/s;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01). Despite regression of left ventricular hypertrophy, there was no associated improvement in diastolic function. In fact, long-term treatment with atenolol\u00b1bendroflumethiazide resulted in a progressive deterioration in E\/e\u2032. This may be a factor contributing to the previously described worse clinical outcome in patients treated with atenolol\u00b1bendroflumethiazide compared with amlodipine\u00b1perindopril.\n          <\/jats:p>","DOI":"10.1161\/hypertensionaha.113.01360","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T05:01:23Z","timestamp":1384232483000},"page":"252-258","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Long-Term Antihypertensive Treatment Fails to Improve E\/e\u2032 Despite Regression of Left Ventricular Mass"],"prefix":"10.1161","volume":"63","author":[{"given":"Anthony J.","family":"Barron","sequence":"first","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alun D.","family":"Hughes","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Sharp","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun J.","family":"Baksi","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Surendran","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Jabbour","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Stanton","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Poulter","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Des","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Sever","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. 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Surendran) and The Conway Institute (D.F., E.O.), University College Dublin, Dublin, Ireland; and Molecular and Cellular Therapeutics, RCSI Research Institute, Royal College of Surgeons in..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Thom","sequence":"additional","affiliation":[{"name":"From the International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom (A.J.B., A.D.H., A. Sharp, A.J.B., N.P., P. Sever, S.T., J.M., R.J.J.); Shields Lab, Complex and Adaptive Systems Laboratory, School of Medicine and Medical Sciences (P. 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