{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:10:49Z","timestamp":1790385049844,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Hypertension contributes to multiple forms of cardiovascular disease and thus morbidity and mortality. The mechanisms inducing hypertension remain unclear although the involvement of homeostatic systems, such as the renin\u2013angiotensin and sympathetic nervous systems, is established. A pivotal role of the angiotensin type 1 receptor in the proximal tubule of the kidney for the development of experimental hypertension is established. Yet, other systems are involved. This study tests whether the expression of angiotensin type 1A receptors in catecholaminergic cells contributes to hypertension development. Using a Cre-lox approach, we deleted the angiotensin type 1A receptor from all catecholaminergic cells. This deletion did not alter basal metabolism or blood pressure but delayed the onset of angiotensin-dependent hypertension and reduced the maximal response. Cardiac hypertrophy was also reduced. The knockout mice showed attenuated activation of the sympathetic nervous system during angiotensin II infusion as measured by spectral analysis of the blood pressure. Increased reactive oxygen species production was observed in forebrain regions, including the subfornical organ, of the knockout mouse but was markedly reduced in the rostral ventrolateral medulla. These studies demonstrate that stimulation of the angiotensin type 1A receptor on catecholaminergic cells is required for the full development of angiotensin-dependent hypertension and support an important role for the sympathetic nervous system in this model.<\/jats:p>","DOI":"10.1161\/hypertensionaha.113.01474","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:52:17Z","timestamp":1378255937000},"page":"866-871","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Stimulation of Angiotensin Type 1A Receptors on Catecholaminergic Cells Contributes to Angiotensin-Dependent Hypertension"],"prefix":"10.1161","volume":"62","author":[{"given":"Nikola","family":"Jancovski","sequence":"first","affiliation":[{"name":"From the Department of Physiology (N.J., J.K.B., D.A.C., Y.-T.C., A.C., D.C., C.M., A.M.A.) and Florey Institute of Neuroscience and Mental Health (A.M.A.), University of Melbourne, Melbourne, Victoria, Australia; Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia (T.-P.N., G.A.H.); and Department of Cardiovascular Regulation, Russian Cardiology Research Center, Moscow, Russia (E.V.L)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet K.","family":"Bassi","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (N.J., J.K.B., D.A.C., Y.-T.C., A.C., D.C., C.M., A.M.A.) and Florey Institute of Neuroscience and Mental Health (A.M.A.), University of Melbourne, Melbourne, Victoria, Australia; Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia (T.-P.N., G.A.H.); and Department of Cardiovascular Regulation, Russian Cardiology Research Center, Moscow, Russia (E.V.L)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Carter","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (N.J., J.K.B., D.A.C., Y.-T.C., A.C., D.C., C.M., A.M.A.) and Florey Institute of Neuroscience and Mental Health (A.M.A.), University of Melbourne, Melbourne, Victoria, Australia; 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