{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:02:01Z","timestamp":1792512121165,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>\n            Cardiac hypertrophy is a complex pathological process that involves multiple factors including inflammation and apoptosis. Interferon regulatory factor 7 (IRF7) is a multifunctional regulator that participates in immune regulation, cell differentiation, apoptosis, and oncogenesis. However, the role of IRF7 in cardiac hypertrophy remains unclear. We performed aortic banding in cardiac-specific IRF7 transgenic mice, IRF7 knockout mice, and the wild-type littermates of these mice. Our results demonstrated that IRF7 was downregulated in aortic banding\u2013induced animal hearts and cardiomyocytes that had been treated with angiotensin II or phenylephrine for 48 hours. Accordingly, heart-specific overexpression of IRF7 significantly attenuated pressure overload\u2013induced cardiac hypertrophy, fibrosis, and dysfunction, whereas loss of IRF7 led to opposite effects. Moreover, IRF7 protected against angiotensin II\u2013induced cardiomyocyte hypertrophy in vitro. Mechanistically, we identified that IRF7-dependent cardioprotection was mediated through IRF7 binding to inhibitor of \u03baB kinase-\u03b2, and subsequent nuclear factor-\u03baB inactivation. In fact, blocking nuclear factor-\u03baB signaling with cardiac-specific inhibitors of \u03baB\u03b1\n            <jats:sup>S32A\/S36A<\/jats:sup>\n            super-repressor transgene counteracted the adverse effect of IRF7 deficiency. Conversely, activation of nuclear factor-\u03baB signaling via a cardiac-specific conditional inhibitor of \u03baB kinase-\u03b2\n            <jats:sup>S177E\/S181E<\/jats:sup>\n            (constitutively active) transgene negated the antihypertrophic effect of IRF7 overexpression. Our data demonstrate that IRF7 acts as a novel negative regulator of pathological cardiac hypertrophy by inhibiting nuclear factor-\u03baB signaling and may constitute a potential therapeutic target for pathological cardiac hypertrophy.\n          <\/jats:p>","DOI":"10.1161\/hypertensionaha.113.02653","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T04:37:51Z","timestamp":1389069471000},"page":"713-722","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy"],"prefix":"10.1161","volume":"63","author":[{"given":"Ding-Sheng","family":"Jiang","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhou","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fei","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gao","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Peng","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gong","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. 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Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Chang","family":"Fan","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), and College of Life Sciences (X.-D.Z., X.-F.Z., K.C.), Wuhan University, Wuhan, China; Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China (L.G.); Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzeng","family":"Zou","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Renmin Hospital (D.-S.J., Y.L., H.Z., Y. Zhang, H.L.), Cardiovascular Research Institute (D.-S.J., Y.L., H.Z., Y. 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Interferon regulatory factor 3 constrains IKK\u03b2\/NF-\u03baB signaling to alleviate hepatic steatosis and insulin resistance. Hepatology. 2013. 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