{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:12:04Z","timestamp":1790615524764,"version":"4.1.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n            Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in\n            <jats:italic>KCNJ5<\/jats:italic>\n            ,\n            <jats:italic>ATP1A1<\/jats:italic>\n            ,\n            <jats:italic>ATP2B3<\/jats:italic>\n            , and\n            <jats:italic>CACNA1D<\/jats:italic>\n            are found in aldosterone-producing adenoma. In addition, adrenals with aldosterone-producing adenomas show cortical remodeling and frequently multiple secondary nodules. Our aim was to investigate whether different aldosterone-producing nodules from the same adrenal share the same mutational status. Aldosterone synthase expression was assessed in multinodular adrenals from 27 patients. DNA of 37 aldosterone-producing secondary nodules was extracted from formalin-fixed paraffin-embedded tissues and genotyped for\n            <jats:italic>KCNJ5<\/jats:italic>\n            ,\n            <jats:italic>ATP1A1<\/jats:italic>\n            ,\n            <jats:italic>ATP2B3<\/jats:italic>\n            , and\n            <jats:italic>CACNA1D<\/jats:italic>\n            mutations. Among 17 adrenals with a somatic mutation in the principal nodule, 4 showed the same mutation in a secondary nodule, whereas 10 had no mutation in any of the known genes. In 1 adrenal harboring the\n            <jats:italic>KCNJ5<\/jats:italic>\n            p.Gly151Arg mutation in the principal nodule, the same mutation was present in 2 secondary nodules, but no mutation was found in a third nodule. Finally, in 2 adrenals with a\n            <jats:italic>CACNA1D<\/jats:italic>\n            mutation in the principal nodule, a\n            <jats:italic>KCNJ5<\/jats:italic>\n            mutation was identified in the secondary nodule. Among 10 adrenals without mutations in the principal nodule, 1 carried a\n            <jats:italic>KCNJ5<\/jats:italic>\n            mutation in the secondary nodule. No mutations were detected in 7 aldosterone-producing cell clusters from 6 adrenals. No association was observed between the presence of mutations in secondary nodules and clinical parameters. In conclusion, different mutations are found in different aldosterone-producing nodules from the same adrenal, suggesting that somatic mutations are independent events triggered by mechanisms that remain to be identified.\n          <\/jats:p>","DOI":"10.1161\/hypertensionaha.115.05993","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T02:38:57Z","timestamp":1441766337000},"page":"1014-1022","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma"],"prefix":"10.1161","volume":"66","author":[{"given":"Fabio Luiz","family":"Fernandes-Rosa","sequence":"first","affiliation":[{"name":"From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Service de G\u00e9n\u00e9tique (F.L.F.-R., M.-C.Z.), Unit\u00e9 Hypertension art\u00e9rielle (L.A.), and Service d\u2019Anatomie Pathologique (T.M.), Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France; and Division of Endocrinology, G.V. (Sonny)..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Giscos-Douriez","sequence":"additional","affiliation":[{"name":"From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Service de G\u00e9n\u00e9tique (F.L.F.-R., M.-C.Z.), Unit\u00e9 Hypertension art\u00e9rielle (L.A.), and Service d\u2019Anatomie Pathologique (T.M.), Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France; and Division of Endocrinology, G.V. (Sonny)..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Amar","sequence":"additional","affiliation":[{"name":"From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Service de G\u00e9n\u00e9tique (F.L.F.-R., M.-C.Z.), Unit\u00e9 Hypertension art\u00e9rielle (L.A.), and Service d\u2019Anatomie Pathologique (T.M.), Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France; and Division of Endocrinology, G.V. (Sonny)..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso E.","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Service de G\u00e9n\u00e9tique (F.L.F.-R., M.-C.Z.), Unit\u00e9 Hypertension art\u00e9rielle (L.A.), and Service d\u2019Anatomie Pathologique (T.M.), Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France; and Division of Endocrinology, G.V. (Sonny)..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tchao","family":"Meatchi","sequence":"additional","affiliation":[{"name":"From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Service de G\u00e9n\u00e9tique (F.L.F.-R., M.-C.Z.), Unit\u00e9 Hypertension art\u00e9rielle (L.A.), and Service d\u2019Anatomie Pathologique (T.M.), Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France; and Division of Endocrinology, G.V. (Sonny)..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheerazed","family":"Boulkroun","sequence":"additional","affiliation":[{"name":"From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Service de G\u00e9n\u00e9tique (F.L.F.-R., M.-C.Z.), Unit\u00e9 Hypertension art\u00e9rielle (L.A.), and Service d\u2019Anatomie Pathologique (T.M.), Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France; and Division of Endocrinology, G.V. (Sonny)..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Christina","family":"Zennaro","sequence":"additional","affiliation":[{"name":"From the INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France (F.L.F.-R., I.G.-D., L.A., T.M., S.B., M.-C.Z.); Service de G\u00e9n\u00e9tique (F.L.F.-R., M.-C.Z.), Unit\u00e9 Hypertension art\u00e9rielle (L.A.), and Service d\u2019Anatomie Pathologique (T.M.), Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France; and Division of Endocrinology, G.V. 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