{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:57:06Z","timestamp":1782172626780,"version":"3.54.5"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n            Aortic stiffness is associated with cognitive decline. Here, we examined the association between carotid-femoral pulse wave velocity and cognitive function and investigated whether cerebrovascular remodeling and parenchymal small vessel disease damage mediate the relation. Analyses were based on 1820 (60% women) participants in the Age, Gene\/Environment Susceptibility\u2014Reykjavik Study. Multivariable linear regression models adjusted for vascular and demographic confounders showed that higher carotid-femoral pulse wave velocity was related to lower memory score (standardized\n            <jats:italic>\u03b2<\/jats:italic>\n            : \u22120.071\u00b10.023;\n            <jats:italic>P<\/jats:italic>\n            =0.002). Cerebrovascular resistance and white matter hyperintensities were each associated with carotid-femoral pulse wave velocity and memory (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). Together, cerebrovascular resistance and white matter hyperintensities (total indirect effect: \u22120.029; 95% CI, \u22120.043 to \u22120.017) attenuated the direct relation between carotid-femoral pulse wave velocity and memory (direct effect: \u22120.042; 95% CI, \u22120.087 to 0.003;\n            <jats:italic>P<\/jats:italic>\n            =0.07) and explained \u224841% of the observed effect. Our results suggest that in older adults, associations between aortic stiffness and memory are mediated by pathways that include cerebral microvascular remodeling and microvascular parenchymal damage.\n          <\/jats:p>","DOI":"10.1161\/hypertensionaha.115.06398","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T03:13:29Z","timestamp":1447730009000},"page":"176-182","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":133,"title":["Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory"],"prefix":"10.1161","volume":"67","author":[{"given":"Leroy L.","family":"Cooper","sequence":"first","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Woodard","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurdur","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"van Buchem","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa A.","family":"Torjesen","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Inker","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Aspelund","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudny","family":"Eiriksdottir","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B.","family":"Harris","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Engineering, Inc, Norwood, MA (L.L.C., T.W., A.A.T., G.F.M.); Cardiovascular Research Center, Rhode Island Hospital, W. Alpert Medical School of Brown University, Providence, RI (L.L.C.); Icelandic Heart Association, Kopavogur, Iceland (S.S., T.A., G.E., V.G.); Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands (M.A.B.); Division of Nephrology and Department of Medicine, Tufts Medical Center, Boston, MA (L.A.I.); Faculty of Medicine, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000257998.33768.87"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.093674"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a43e1c"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.07.032"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3182949f06"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061855"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.126342"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000170384.38708.b7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.099291"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128420.01881.aa"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90549.2008"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk115"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.108175"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000020500.77568.3c"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.024"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10133"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.13.1.8"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/54B.3.P155"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200002)47:2<145::AID-ANA3>3.0.CO;2-P"},{"key":"e_1_3_3_23_2","first-page":"165","volume-title":"In: Clinical Gerontology: A Guide to Assessment and Intervention","author":"Sheikh JI","year":"1986","unstructured":"Sheikh JI, Yesavage JA. 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