{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:15:01Z","timestamp":1781662501012,"version":"3.54.5"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Carotid bodies play a critical role in protecting against hypoxemia, and their activation increases sympathetic activity, arterial pressure, and ventilation, responses opposed by acute stimulation of the baroreflex. Although chemoreceptor hypersensitivity is associated with sympathetically mediated hypertension, the mechanisms involved and their significance in the pathogenesis of hypertension remain unclear. We investigated the chronic interactions of these reflexes in dogs with sympathetically mediated, obesity-induced hypertension based on the hypothesis that hypoxemia and tonic activation of carotid chemoreceptors may be associated with obesity. After 5 weeks on a high-fat diet, the animals experienced a 35% to 40% weight gain and increases in arterial pressure from 106\u00b13 to 123\u00b13 mm\u2009Hg and respiratory rate from 8\u00b11 to 12\u00b11 breaths\/min along with hypoxemia (arterial partial pressure of oxygen=81\u00b13 mm\u2009Hg) but eucapnia. During 7 days of carotid baroreflex activation by electric stimulation of the carotid sinus, tachypnea was attenuated, and hypertension was abolished before these variables returned to prestimulation values during a recovery period. After subsequent denervation of the carotid sinus region, respiratory rate decreased transiently in association with further sustained reductions in arterial partial pressure of oxygen (to 65\u00b12 mm\u2009Hg) and substantial hypercapnia. Moreover, the severity of hypertension was attenuated from 125\u00b12 to 116\u00b13 mm\u2009Hg (45%\u201350% reduction). These findings suggest that hypoxemia may account for sustained stimulation of peripheral chemoreceptors in obesity and that this activation leads to compensatory increases in ventilation and central sympathetic outflow that contributes to neurogenically mediated hypertension. Furthermore, the excitatory effects of chemoreceptor hyperactivity are abolished by chronic activation of the carotid baroreflex.<\/jats:p>","DOI":"10.1161\/hypertensionaha.116.07232","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T04:25:45Z","timestamp":1462854345000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Chronic Interactions Between Carotid Baroreceptors and Chemoreceptors in Obesity Hypertension"],"prefix":"10.1161","volume":"68","author":[{"given":"Thomas E.","family":"Lohmeier","sequence":"first","affiliation":[{"name":"From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (T.E.L.); Department of Pharmacology (R.I.) and Department of Physiology (I.T.), University of Medicine and Pharmacy, \u201cGr. T. Popa,\u201d Iasi, Romania; Colonial Pipeline Company, Atlanta, GA (R.C.); CVRx, Inc., Minneapolis, MN (A.W.C., D.G.); and North Memorial Medical Center, Trauma Services, Robbinsdale, MN (E.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Iliescu","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (T.E.L.); Department of Pharmacology (R.I.) and Department of Physiology (I.T.), University of Medicine and Pharmacy, \u201cGr. T. Popa,\u201d Iasi, Romania; Colonial Pipeline Company, Atlanta, GA (R.C.); CVRx, Inc., Minneapolis, MN (A.W.C., D.G.); and North Memorial Medical Center, Trauma Services, Robbinsdale, MN (E.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionut","family":"Tudorancea","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (T.E.L.); Department of Pharmacology (R.I.) and Department of Physiology (I.T.), University of Medicine and Pharmacy, \u201cGr. T. Popa,\u201d Iasi, Romania; Colonial Pipeline Company, Atlanta, GA (R.C.); CVRx, Inc., Minneapolis, MN (A.W.C., D.G.); and North Memorial Medical Center, Trauma Services, Robbinsdale, MN (E.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Cazan","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (T.E.L.); Department of Pharmacology (R.I.) and Department of Physiology (I.T.), University of Medicine and Pharmacy, \u201cGr. T. Popa,\u201d Iasi, Romania; Colonial Pipeline Company, Atlanta, GA (R.C.); CVRx, Inc., Minneapolis, MN (A.W.C., D.G.); and North Memorial Medical Center, Trauma Services, Robbinsdale, MN (E.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam W.","family":"Cates","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (T.E.L.); Department of Pharmacology (R.I.) and Department of Physiology (I.T.), University of Medicine and Pharmacy, \u201cGr. T. Popa,\u201d Iasi, Romania; Colonial Pipeline Company, Atlanta, GA (R.C.); CVRx, Inc., Minneapolis, MN (A.W.C., D.G.); and North Memorial Medical Center, Trauma Services, Robbinsdale, MN (E.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Georgakopoulos","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (T.E.L.); Department of Pharmacology (R.I.) and Department of Physiology (I.T.), University of Medicine and Pharmacy, \u201cGr. T. Popa,\u201d Iasi, Romania; Colonial Pipeline Company, Atlanta, GA (R.C.); CVRx, Inc., Minneapolis, MN (A.W.C., D.G.); and North Memorial Medical Center, Trauma Services, Robbinsdale, MN (E.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Irwin","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (T.E.L.); Department of Pharmacology (R.I.) and Department of Physiology (I.T.), University of Medicine and Pharmacy, \u201cGr. T. 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