{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:07:26Z","timestamp":1789189646487,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Aortic stiffness, a cardiovascular risk factor, depends on the operating mean arterial pressure (MAP). The impact of aortic stiffness on cardiovascular outcomes is proposed to be mediated by the attenuation or the reversal of the arterial stiffness gradient. We hypothesized that arterial stiffness gradient is less influenced by changes in MAP. We aimed to study the relationship between MAP and aortic stiffness, brachial stiffness, and arterial stiffness gradient. In a cross-sectional study of a dialysis cohort (group A, n=304) and a cohort of hypertensive or kidney transplant recipient with an estimated glomerular filtration rate of &gt;45 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    (group B, n=114), we assessed aortic and brachial stiffness by measuring carotid\u2013femoral and carotid\u2013radial pulse wave velocities (PWV). We used aortic\u2013brachial PWV ratio as a measure of arterial stiffness gradient. Although there was a positive relationship between MAP and carotid\u2013femoral PWV (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =0.10 and 0.08;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001 and\n                    <jats:italic>P<\/jats:italic>\n                    =0.003) and MAP and carotid\u2013radial PWV (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =0.22 and 0.12;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001 and\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001), there was no statistically or clinically significant relationship between MAP and aortic\u2013brachial PWV ratio (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =0.0002 and 0.0001;\n                    <jats:italic>P<\/jats:italic>\n                    =0.8 and\n                    <jats:italic>P<\/jats:italic>\n                    =0.9) in group A and B, respectively. Dialysis status and increasing age increased the slope of the relationship between MAP and cf-PWV. However, we found no modifying factor (age, sex, dialysis status, diabetes mellitus, cardiovascular disease, and class of antihypertensive drugs) that could affect the lack of relationship between MAP and aortic\u2013brachial PWV ratio. In conclusion, these results suggest that aortic\u2013brachial PWV ratio could be considered as a blood pressure\u2013independent measure of vascular aging.\n                  <\/jats:p>","DOI":"10.1161\/hypertensionaha.116.08409","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T23:04:13Z","timestamp":1478559853000},"page":"96-101","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Aortic\u2013Brachial Pulse Wave Velocity Ratio"],"prefix":"10.1161","volume":"69","author":[{"given":"Catherine","family":"Fortier","sequence":"first","affiliation":[{"name":"From the CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec Hospital, Qu\u00e9bec City, Canada (C.F., A.S., M.-P.D., K.M., S.A.D.S., F.M., M.A.); and Division of Nephrology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada (C.F., A.S., M.-P.D., S.A.D.S., F.M., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubacar","family":"Sidib\u00e9","sequence":"additional","affiliation":[{"name":"From the CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec Hospital, Qu\u00e9bec City, Canada (C.F., A.S., M.-P.D., K.M., S.A.D.S., F.M., M.A.); and Division of Nephrology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada (C.F., A.S., M.-P.D., S.A.D.S., F.M., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pier","family":"Desjardins","sequence":"additional","affiliation":[{"name":"From the CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec Hospital, Qu\u00e9bec City, Canada (C.F., A.S., M.-P.D., K.M., S.A.D.S., F.M., M.A.); and Division of Nephrology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada (C.F., A.S., M.-P.D., S.A.D.S., F.M., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Marquis","sequence":"additional","affiliation":[{"name":"From the CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec Hospital, Qu\u00e9bec City, Canada (C.F., A.S., M.-P.D., K.M., S.A.D.S., F.M., M.A.); and Division of Nephrology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada (C.F., A.S., M.-P.D., S.A.D.S., F.M., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha A.","family":"De Serres","sequence":"additional","affiliation":[{"name":"From the CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec Hospital, Qu\u00e9bec City, Canada (C.F., A.S., M.-P.D., K.M., S.A.D.S., F.M., M.A.); and Division of Nephrology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada (C.F., A.S., M.-P.D., S.A.D.S., F.M., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Mac-Way","sequence":"additional","affiliation":[{"name":"From the CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec Hospital, Qu\u00e9bec City, Canada (C.F., A.S., M.-P.D., K.M., S.A.D.S., F.M., M.A.); and Division of Nephrology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada (C.F., A.S., M.-P.D., S.A.D.S., F.M., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Agharazii","sequence":"additional","affiliation":[{"name":"From the CHU de Qu\u00e9bec Research Center, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec Hospital, Qu\u00e9bec City, Canada (C.F., A.S., M.-P.D., K.M., S.A.D.S., F.M., M.A.); and Division of Nephrology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada (C.F., A.S., M.-P.D., S.A.D.S., F.M., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.18.2434"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.197210"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.5.1111"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1236"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033824.02722.F7"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90549.2008"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000438852"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.101"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01318"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04587"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200106000-00007"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01200"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.3.485"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.7.1827"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(80)90191-8"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.13.101"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.2.637"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.098298"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.7.2133"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000655"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/HYPERTENSIONAHA.116.08409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:20:30Z","timestamp":1715577630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/HYPERTENSIONAHA.116.08409"}},"subtitle":["A Blood Pressure\u2013Independent Index of Vascular Aging"],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1161\/HYPERTENSIONAHA.116.08409"],"URL":"https:\/\/doi.org\/10.1161\/hypertensionaha.116.08409","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}