{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:56:51Z","timestamp":1790873811563,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Animal models support a role for the gut microbiota in the development of hypertension. There has been a lack of epidemiological cohort studies to confirm these findings in human populations. We examined cross-sectional associations between measures of gut microbial diversity and taxonomic composition and blood pressure (BP) in 529 participants of the biracial (black and white) CARDIA study (Coronary Artery Risk Development in Young Adults). We sequenced V3-V4 regions of the 16S ribosomal RNA marker gene using DNA extracted from stool samples collected at CARDIA\u2019s Year 30 follow-up examination (2015\u20132016; aged 48\u201360 years). We quantified associations between BP (hypertension [defined as systolic BP \u2265140 mm\u2009Hg or diastolic BP \u226590 mm\u2009Hg or antihypertension medication use] and systolic BP) and within and between-person diversity measures. We conducted genera-specific multivariable-adjusted regression analysis, accounting for multiple comparisons using the false discovery rate. Hypertension and systolic BP were inversely associated with measures of \u03b1-diversity, including richness and the Shannon Diversity Index, and were distinguished with respect to principal coordinates based on a similarity matrix of genera abundance. Several specific genera were significantly associated with hypertension and systolic BP, though results were attenuated with adjustment for body mass index. Our findings support associations between within-person and between-person gut microbial community diversity and taxonomic composition and BP in a diverse population-based cohort of middle-aged adults. Future study is needed to define functional pathways that underlie observed associations and identify specific microbial targets for intervention.<\/jats:p>","DOI":"10.1161\/hypertensionaha.118.12109","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T09:00:24Z","timestamp":1553504424000},"page":"998-1006","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":265,"title":["Gut Microbiota Composition and Blood Pressure"],"prefix":"10.1161","volume":"73","author":[{"given":"Shan","family":"Sun","sequence":"first","affiliation":[{"name":"From the Department of Bioinformatics, University of North Carolina at Charlotte (S.S., M.S., K.W., A.A.F.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Lulla","sequence":"additional","affiliation":[{"name":"Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC (A.L., 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