{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:37:09Z","timestamp":1791311829648,"version":"4.3.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>There is little evidence evaluating angiogenic growth factor testing in real-world obstetric settings. This investigation evaluated maternal and perinatal pregnancy outcomes associated with maternal PlGF (placental growth factor) levels in real-world clinical care of high-risk pregnancies. From March 2017 to December 2019, 979 pregnant women with suspected risk of placental dysfunction, hypertensive disorders of pregnancy, or fetal growth restriction completed PlGF testing between 20+0 and 35+6 weeks of gestation. Maternal, fetal, and delivery characteristics were extracted through the electronic medical record system. The primary outcome of preterm birth was assessed using Royston-Parmar survival models and summarized with Kaplan-Meier methods. Of the 979 pregnant women, 289 had low PlGF levels (29.5%), and 690 had normal PlGF levels (70.5%). The survival probability of ongoing pregnancy free from preterm birth within 2- and 4-weeks following PlGF testing was significantly reduced in women with low PlGF levels, relative to women with normal PlGF levels (0.57 versus 0.99, standardized survival difference, \u22120.43 [95% CI, \u22120.76 to \u22120.09], and 0.37 versus 0.99, standardized survival difference, \u22120.62 [95% CI \u22120.87 to \u22120.38], respectively). Women with low PlGF levels were more likely to develop early-onset preeclampsia (adjusted odds ratio, 58.2 [95% CI, 32.1\u2013105.4]) and have a stillbirth (adjusted odds ratio, 15.9 [95% CI, 7.6\u201333.3]). PlGF status distinguished placental from fetal causes of stillbirth. Low PlGF levels in high-risk pregnant women are strongly associated with increased rates of imminent preterm birth, as well as related adverse outcomes, including early-onset preeclampsia and stillbirth.<\/jats:p>","DOI":"10.1161\/hypertensionaha.121.17047","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T09:01:35Z","timestamp":1618218095000},"page":"2057-2065","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["PlGF (Placental Growth Factor) Testing in Clinical Practice: Evidence From a Canadian Tertiary Maternity Referral Center"],"prefix":"10.1161","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-0606","authenticated-orcid":true,"given":"Kelsey","family":"McLaughlin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.), Sinai Health System, Toronto, Canada."},{"name":"The Research Centre for Women\u2019s and Infants\u2019 Health, Lunenfeld-Tanenbaum Research Institute (K.M., M.C.A., J.C.K.), Sinai Health System, Toronto, Canada."},{"name":"Division of Cardiology, Department of Internal Medicine (K.M.), Sinai Health System, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7128-8916","authenticated-orcid":true,"given":"John W.","family":"Snelgrove","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.), Sinai Health System, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3619-6298","authenticated-orcid":true,"given":"Melanie C.","family":"Audette","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.), Sinai Health System, Toronto, Canada."},{"name":"The Research Centre for Women\u2019s and Infants\u2019 Health, Lunenfeld-Tanenbaum Research Institute (K.M., M.C.A., J.C.K.), Sinai Health System, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Syed","sequence":"additional","affiliation":[{"name":"Information Services (A.D., S.C.), Sinai Health System, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian R.","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.), Sinai Health System, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory C.","family":"Windrim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.), Sinai Health System, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Melamed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada (N.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Carmona","sequence":"additional","affiliation":[{"name":"Information Services (A.D., S.C.), Sinai Health System, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-5535","authenticated-orcid":true,"given":"John C.","family":"Kingdom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.), Sinai Health System, Toronto, 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