{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:36:44Z","timestamp":1793299004810,"version":"4.5.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Hypertensive disorders of pregnancy are a leading cause of severe maternal morbidity and mortality and confer 4-fold higher perinatal mortality in Black women. Early pregnancy blood pressure patterns may differentiate risk of hypertensive disorders of pregnancy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This study identified distinct blood pressure trajectories from 0 to 20 weeks\u2019 gestation to evaluate subsequent pregnancy-related hypertension in a retrospective cohort of 174\u2009925 women with no prior hypertension or history of preeclampsia, prenatal care entry \u226414 weeks, and a stillborn or live singleton birth delivered at Kaiser Permanente Northern California hospitals in 2009 to 2019. We used electronic health records to obtain clinical outcomes, covariables, and longitudinal outpatient blood pressure measurements \u226420 weeks\u2019 gestation (mean 4.1 measurements). Latent class trajectory modeling identified 6 blood pressure groups: ultra-low-declining(referent), low-declining, moderate-fast-decline, low-increasing, moderate-stable, and elevated-stable. Multivariable logistic regression evaluated trajectory group-associations with the odds of preeclampsia\/eclampsia and gestational hypertension\u201a and effect modification by race-ethnicity and prepregnancy body size.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Compared with ultra-low-declining, adjusted odds ratios (95% confidence intervals [CIs]) for low-increasing, moderate-stable, and elevated-stable groups were 3.25 (2.7\u20133.9), 5.3 (4.5\u20136.3), and 9.2 (7.7\u201311.1) for preeclampsia\/eclampsia\u201a and 6.4 (4.9\u20138.3), 13.6 (10.5\u201317.7), and 30.2 (23.2\u201339.4) for gestational hypertension. Race\/ethnicity, and prepregnancy obesity modified the trajectory-group associations with preeclampsia\/eclampsia (interaction\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), with highest risks for Black, then Hispanic and Asian women for all blood pressure trajectories, and with increasing obesity class.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Early pregnancy blood pressure patterns revealed racial and ethnic differences in associations with preeclampsia\/eclampsia risk within equivalent levels and patterns. These blood pressure patterns may improve individual risk stratification permitting targeted surveillance and early mitigation strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/hypertensionaha.121.18568","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T10:00:47Z","timestamp":1640772047000},"page":"599-613","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Early Pregnancy Blood Pressure Patterns Identify Risk of Hypertensive Disorders of Pregnancy Among Racial and Ethnic Groups"],"prefix":"10.1161","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-1964","authenticated-orcid":true,"given":"Erica P.","family":"Gunderson","sequence":"first","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, CA (E.P.G., M.N.N.-H., A.S.G., W.T., S.E.A.)"},{"name":"the Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA (E.P.G., A.S.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaiser Permanente, Oakland Medical Center, CA (M.G., C.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8228-0282","authenticated-orcid":true,"given":"Mai N.","family":"Nguyen-Huynh","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, CA (E.P.G., M.N.N.-H., A.S.G., W.T., S.E.A.)"},{"name":"Department of Neurology, Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA (M.N.N.-H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy","family":"Tierney","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaiser Permanente, Oakland Medical Center, CA (M.G., C.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-3207","authenticated-orcid":true,"given":"James M.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, Epidemiology and Clinical and Translational Research, University of Pittsburgh, PA (J.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-0811","authenticated-orcid":true,"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, CA (E.P.G., M.N.N.-H., A.S.G., W.T., S.E.A.)"},{"name":"the Department of Health Systems Science, Kaiser Permanente Bernard J. 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