{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:26:14Z","timestamp":1790025974682,"version":"4.0.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Whether time-in-target range (TTR) for systolic blood pressure (SBP) associates with adverse kidney and cardiovascular events remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This study included participants in 2 clinical trials that compared intensive (&lt;120 mm\u2009Hg) and standard (&lt;140 mm\u2009Hg) SBP lowering. SBP-TTR for months 0 to 3 was calculated using therapeutic ranges of 110 to 130 mm\u2009Hg and 120 to 140 mm\u2009Hg for the intensive and standard arms, respectively. Adverse kidney events included the composite of dialysis, kidney transplant, serum creatinine &gt;3.3 mg\/dL, sustained eGFR &lt;15 mL\/(min\u00b71.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ), or sustained eGFR decline &gt;40%. Adverse cardiovascular events included myocardial infarction, stroke, heart failure, and cardiovascular death. Adjusted Cox proportional hazards regression models were used to estimate the association between SBP-TTR and kidney and cardiovascular events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Participants with higher TTR were younger and less likely to have preexisting cardiovascular disease. Compared with participants with TTR of 0%, the risk of adverse kidney events was lower for participants with TTR of &gt;0% to 43% (hazard ratio [95% CI], 0.57 [0.42\u20130.76];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), 43% to &lt;70% (0.57 [0.42\u20130.78];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001), 70% to &lt;100% (0.53 [0.38\u20130.74];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and 100% (0.33 [0.20\u20130.57];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) in fully adjusted models. The risk of major adverse cardiovascular events was lower for participants with TTR of &gt;0% to 43% (0.66 [0.52\u20130.83];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001), 43% to &lt;70% (0.70 [0.55\u20130.90];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.005), 70% to &lt;100% (0.65 [0.50\u20130.84];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001), or 100% (0.56 [0.39\u20130.80];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001) compared with those with TTR of 0%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Higher SBP-TTR associates with lower risks of adverse kidney and cardiovascular events in adults with hypertension. SBP-TTR may be a potential therapeutic target and quality metric.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.122.20141","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T05:00:59Z","timestamp":1666069259000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Systolic Blood Pressure Time in Target Range and Major Adverse Kidney and Cardiovascular Events"],"prefix":"10.1161","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-1486","authenticated-orcid":true,"given":"Leo F.","family":"Buckley","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, Brigham and Women\u2019s Hospital, MA (L.F.B., O.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2172-0931","authenticated-orcid":true,"given":"William L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Connecticut (W.L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0688-4487","authenticated-orcid":true,"given":"Benjamin W.","family":"Van Tassell","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University (B.W.V.T., D.L.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-079X","authenticated-orcid":true,"given":"Jordana B.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pennsylvania (J.B.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7714-2945","authenticated-orcid":true,"given":"Omar","family":"Alkhezi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Brigham and Women\u2019s Hospital, MA (L.F.B., O.A.)."},{"name":"Pharmacy Practice Department, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia (O.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-5039","authenticated-orcid":true,"given":"Adam P.","family":"Bress","sequence":"additional","affiliation":[{"name":"University of Utah (A.P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-9521","authenticated-orcid":true,"given":"Dave L.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University (B.W.V.T., D.L.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032582"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19043"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13551"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.16501"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0885"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1366"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111437"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202359"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007131"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.01.014"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.01.013"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0488"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.12.013"},{"key":"e_1_3_3_17_2","first-page":"1","article-title":"Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.","volume":"6736","author":"Xie X","year":"2015","unstructured":"Xie, X, Atkins, E, Lv, J, Bennett, A, Neal, B, Ninomiya, T, et al. 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