{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:17:04Z","timestamp":1786555024547,"version":"build-2736575974"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>High blood pressure (BP) in middle-aged and older adults is associated with a brain white matter (WM) microstructural abnormality. However, little evidence is available in healthy young adults. We investigated the associations between high BP and WM microstructural integrity in young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      This study included 1015 healthy young adults (542 women, 22\u201337 years) from the Human Connectome Project. Brachial systolic and diastolic BP were measured using a semiautomatic or manual sphygmomanometer. Diffusion-weighted magnetic resonance imaging was acquired to obtain diffusion tensor imaging metrics of free water (FW) content, FW-corrected WM fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity. Using whole-brain voxel-wise linear regression models and ANCOVA, we examined associations of BP and hypertension stage with diffusion tensor imaging metrics after adjusting for age, sex, education, body mass index, smoking status, alcohol consumption history, and differences in the\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      value used for diffusion magnetic resonance imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Systolic and diastolic BP of the sample (mean\u00b1SD) were 122.8\u00b113.0 and 76.0\u00b19.9 mm\u2005Hg, respectively. Associations of BP with diffusion tensor imaging metrics revealed regional heterogeneity for FW-corrected fractional anisotropy. High BP and high hypertension stage were associated with higher FW and lower FW-corrected axial diffusivity, FW-corrected radial diffusivity, and FW-corrected mean diffusivity. Moreover, associations of high diastolic BP and hypertension stage with high FW were found only in men not in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>High BP in young adults is associated with altered brain WM microstructural integrity, suggesting that high BP may have damaging effects on brain WM microstructural integrity in early adulthood, particularly in men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.123.22337","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T05:00:31Z","timestamp":1710478831000},"page":"1145-1155","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Association of Blood Pressure With Brain White Matter Microstructural Integrity Assessed With MRI Diffusion Tensor Imaging in Healthy Young Adults"],"prefix":"10.1161","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7900-9355","authenticated-orcid":true,"given":"Junyeon","family":"Won","sequence":"first","affiliation":[{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (J.W., K.S., J.A., D.C., R.Z.)."},{"name":"Departments of Neurology (J.W., K.S., J.A., D.C., R.Z.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3516-6345","authenticated-orcid":true,"given":"Pauline","family":"Maillard","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, Davis (P.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-0387","authenticated-orcid":true,"given":"Kevin","family":"Shan","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (J.W., K.S., J.A., D.C., R.Z.)."},{"name":"Departments of Neurology (J.W., K.S., J.A., D.C., R.Z.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-424X","authenticated-orcid":true,"given":"John","family":"Ashley","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (J.W., K.S., J.A., D.C., R.Z.)."},{"name":"Departments of Neurology (J.W., K.S., J.A., D.C., R.Z.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-1321","authenticated-orcid":true,"given":"Danilo","family":"Cardim","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (J.W., K.S., J.A., D.C., R.Z.)."},{"name":"Departments of Neurology (J.W., K.S., J.A., D.C., R.Z.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-0144","authenticated-orcid":true,"given":"David C.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing (D.C.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-5216","authenticated-orcid":true,"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (J.W., K.S., J.A., D.C., R.Z.)."},{"name":"Departments of Neurology (J.W., K.S., J.A., D.C., R.Z.), University of Texas Southwestern Medical Center, Dallas."},{"name":"Internal Medicine (R.Z.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","volume-title":"Hypertension Cascade: Hypertension Prevalence, Treatment and Control Estimates Among US Adults Aged 18 Years and Older Applying the Criteria from the American College of Cardiology and American Heart Association\u2019s 2017 Hypertension Guideline\u2014NHANES 2013\u20132016","author":"Centers for Disease Control and Prevention (CDC)","year":"2019","unstructured":"Centers for Disease Control and Prevention (CDC). 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