{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:38:58Z","timestamp":1777415938066,"version":"3.51.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Catheter-based renal denervation (RDN) reduces blood pressure in hypertension. Urinary peptides are associated with cardiovascular and renal disease and provide prognostic information. We aimed to investigate the effect of RDN on urinary peptide-based classifiers associated with chronic kidney and heart disease and to identify urinary peptides affected by RDN.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>This single-arm, single-center study included patients undergoing catheter-based RDN. Urine samples were collected before and 24 months after RDN and were analyzed using capillary electrophoresis coupled with mass spectrometry. Predefined urinary peptide-based classifiers for chronic kidney disease (CKD273), coronary artery disease (CAD238), and heart failure (HF1) were applied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              This study included 48 patients (33% female) with uncontrolled hypertension. At 24 months after RDN, systolic blood pressure (165\u00b117 versus 148\u00b120 mm\u2005Hg;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001), diastolic blood pressure (90\u00b117 versus 81\u00b113 mm\u2005Hg;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001), and mean arterial pressure (115\u00b115 versus 103\u00b113 mm\u2005Hg;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.0001) decreased significantly. A total of 103 urinary peptides from 37 different proteins, mostly collagens, altered following RDN. CAD238, a 238 coronary artery-specific polypeptide-based classifier, significantly improved following RDN (Cohen\u2019s\n              <jats:italic toggle=\"yes\">d<\/jats:italic>\n              , \u22120.632;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.0001). The classification scores of HF1 (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.8295) and CKD273 (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.6293) did not change significantly.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>RDN beneficially affected urinary peptides associated with coronary artery disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01888315.\n            <\/jats:p>\n          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and Hypertension), Medical University Innsbruck, Austria (F.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-2209","authenticated-orcid":true,"given":"Michael","family":"Kunz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III \u2013 Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tskliniken des Saarlandes und Universit\u00e4t des Saarlandes, Homburg, Germany (L.L., M.K., A.W., I.E.E., M.B., F.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Wachter","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III \u2013 Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tskliniken des Saarlandes und Universit\u00e4t des Saarlandes, Homburg, Germany (L.L., M.K., A.W., I.E.E., M.B., 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