{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:03:22Z","timestamp":1784966602374,"version":"3.55.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Ciliary neurotrophic factor (CNTF), mainly known for its neuroprotective properties, belongs to the IL-6 (interleukin-6) cytokine family. In contrast to IL-6, the effects of CNTF on the vasculature have not been explored. Here, we examined the role of CNTF in AngII (angiotensin II)-induced hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Hypertension was chronically induced with AngII (1000 ng\/kg per minute, osmotic mini-pumps, 14 days) in CNTF-knockout and wild-type mice (with or without nephrectomy and 1% NaCl drinking water). Blood pressure was measured by tail-cuff and radiotelemetry. Effects of CNTF on vascular function and the JAK2\/STAT3 pathway were measured in vivo, in the isolated perfused kidney, and in mouse and human vascular smooth muscle cells.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>At baseline, systolic blood pressure was similar between both groups. During AngII infusion, blood pressure increase was significantly attenuated and hypertensive heart and kidney damage was significantly attenuated in CNTF-knockout compared with wild-type mice. Accordingly, renal pressor response to AngII but not KCl or phenylephrine was significantly decreased in CNTF-knockout compared with wild-type mice. Acute CNTF (5 \u00b5mol\/L) administration nearly restored the AngII-dependent renal pressor response. Chronic CNTF treatment in CNTF-knockout mice increased blood pressure response to AngII to levels observed in wild-type mice. CNTF augments AngII-induced activation of the JAK2\/STAT3 pathway in vitro in vascular smooth muscle cells. The significance of this interaction was shown, as the increase in renal pressor response by CNTF was abolished by JAK2\/STAT3 inhibitors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Our results demonstrate a major impact of CNTF on blood pressure regulation by modulating AngII-induced pressor response via a JAK2\/STAT3-dependent mechanism and indicate that CNTF is an important regulatory cytokine in hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.22845","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T10:01:13Z","timestamp":1737712873000},"page":"652-664","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Role of Ciliary Neurotrophic Factor in Angiotensin II-Induced Hypertension"],"prefix":"10.1161","volume":"82","author":[{"given":"Sebastian A.","family":"Potthoff","sequence":"first","affiliation":[{"name":"Department of Nephrology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Quack","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-0559","authenticated-orcid":true,"given":"Yuri","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Faculty of Heinrich Heine University, University Hospital D\u00fcsseldorf, Germany (Y.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-7079","authenticated-orcid":true,"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Peking University Shenzhen Hospital, China (G.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2759-6999","authenticated-orcid":true,"given":"Denada","family":"Arifaj","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2995-8864","authenticated-orcid":true,"given":"Ehsan","family":"Amin","sequence":"additional","affiliation":[{"name":"Institute of Neural and Sensory Physiology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (E.A.)."},{"name":"Institute of Biochemistry and Molecular Biology II, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (E.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-1815","authenticated-orcid":true,"given":"Jaroslawna","family":"Meister","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf, Germany; German Center for Diabetes Research, Germany (J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-3501","authenticated-orcid":true,"given":"Sven G.","family":"Meuth","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, Heinrich Heine University of D\u00fcsseldorf, Germany (S.G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Kantauskaite","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1020-6384","authenticated-orcid":true,"given":"Doron","family":"Argov","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Alesutan","sequence":"additional","affiliation":[{"name":"Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria (I.A., J.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-5087","authenticated-orcid":true,"given":"Jakob","family":"Voelkl","sequence":"additional","affiliation":[{"name":"Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria (I.A., J.V.)."},{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Germany (J.V.)."},{"name":"German Centre for Cardiovascular Research, Berlin, Germany (J.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon-Keun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Hannover Medical School, Germany (J.-K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars C.","family":"Rump","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.)."},{"name":"Cardiovascular Research Institute D\u00fcsseldorf, Medical Faculty, Heinrich Heine University, Germany (L.C.R., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2751-3653","authenticated-orcid":true,"given":"Marc","family":"Rio","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire de Nantes, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, l\u2019institut du thorax, France (M.R., G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-3931","authenticated-orcid":true,"given":"Gervaise","family":"Loirand","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Centre Hospitalier Universitaire de Nantes, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, l\u2019institut du thorax, France (M.R., G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf A.","family":"Linker","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Regensburg, Germany (R.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-8102","authenticated-orcid":true,"given":"Johannes","family":"Stegbauer","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical Faculty, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Germany (S.A.P., I.Q., D. Arifaj, M.K., D. Argov, L.C.R., J.S.)."},{"name":"Cardiovascular Research Institute D\u00fcsseldorf, Medical Faculty, Heinrich Heine University, Germany (L.C.R., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2013.00044"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0602-620"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.03.071"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.021"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V124749"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01745045"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00493-X"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.514"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00634.2014"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104312"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2011.12.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001845"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140265.21608.8E"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.113"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.158071"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2079"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0210-165"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7010019"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.568857"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1586\/ern.13.9"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2493-5"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061078"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003128200"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32833283e6"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.22729"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200107009"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020302"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00708.2005"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1024180101032"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413187200"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107657"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30453"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.017"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00974.2011"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88641"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019060599"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-013-0340-9"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.21.099"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605545103"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14079"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000358"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.01.111"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.01.020"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121468"},{"key":"e_1_3_3_47_2","first-page":"1183","article-title":"Evaluation of early renal involvement in essential hypertension by measuring urinary biomarkers.","volume":"31","author":"Morshed MR","year":"2022","unstructured":"Morshed MR, Ashraf I, Hussain MZ, Khan TA, Anwar MI, Imtiaz MN, Alam MA, Siddiqui NA, Ahmed AS. 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