{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:38:51Z","timestamp":1793147931375,"version":"4.5.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Hs-cTnT (cardiac troponin T measured with a highly sensitive assay) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) may identify adults with hypertension who derive greater cognitive benefits from lower systolic blood pressure targets.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>In the SPRINT (Systolic Blood Pressure Intervention Trial) MIND study, participants were categorized as having both hs-cTnT and NT-proBNP in the lower 2 tertiles (n=4226), one in the highest tertile (n=2379), and both in the highest tertile (n=1506). We assessed the effect of intensive versus standard treatment on the composite of mild cognitive impairment (MCI) or probable dementia (PD) across biomarker categories.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Over a median follow-up of 5.1 years, 830 of 8111 participants (10.2%) developed MCI or PD. Participants in the highest biomarker category were at higher risk of MCI or PD compared with those in the lowest category (hazard ratio, 1.34 [95% CI, 1.00\u20131.56]). The effect of intensive treatment on reducing the risk of MCI or PD was greater among participants in the lowest biomarker category (hazard ratio, 0.64 [95% CI, 0.50\u20130.81]) than those in the intermediate (hazard ratio, 1.01 [95% CI, 0.80\u20131.28]) or highest categories (hazard ratio, 0.90 [95% CI, 0.72\u20131.13];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.02). The 5-year absolute risk differences in MCI or PD with intensive treatment were \u22122.9% (\u22124.4%, \u22121.3%), \u22120.2% (\u22123.0%, 2.6%), and \u22121.9% (\u22126.2%, 2.4%) in the lowest, intermediate, and highest biomarker categories, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In SPRINT, the relative effect of intensive systolic blood pressure lowering on preventing cognitive impairment appears to be stronger among participants with lower compared with higher cardiac biomarker levels, though the absolute risk reductions were similar.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.22876","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T09:01:02Z","timestamp":1719997262000},"page":"1956-1965","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["High-Sensitivity Troponin T, NT-proBNP, and Cognitive Outcomes in SPRINT"],"prefix":"10.1161","volume":"81","author":[{"given":"Devin","family":"Haney","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas at Tyler Health Science Center (D.H., D.D., J.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0207-3620","authenticated-orcid":true,"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (Y.M., W.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-3002","authenticated-orcid":true,"given":"Djhenne","family":"Dalmacy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas at Tyler Health Science Center (D.H., D.D., J.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4447-6196","authenticated-orcid":true,"given":"Nicholas M.","family":"Pajewski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC (N.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Department of Neurology (I.H.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-7261","authenticated-orcid":true,"given":"James A.","family":"de Lemos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine (J.A.d.L.), University of Texas Southwestern Medical Center, Dallas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (Y.M., W.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-8150","authenticated-orcid":true,"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Division of Public Health Sciences and Department of Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, NC (E.Z.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-1730","authenticated-orcid":true,"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[{"name":"Department of Medicine and Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, Houston, TX (C.M.B., V.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-0267","authenticated-orcid":true,"given":"Vijay","family":"Nambi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, Houston, TX (C.M.B., V.N.)."},{"name":"Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (V.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1604-2593","authenticated-orcid":true,"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom (N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-9468","authenticated-orcid":true,"given":"Anthony A.","family":"Killeen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (A.A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-9869","authenticated-orcid":true,"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[{"name":"Nephrology Section, Veterans Affairs San Diego Healthcare System, CA (J.H.I.)."},{"name":"Division of Nephrology-Hypertension, University of California San Diego (J.H.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9559-204X","authenticated-orcid":true,"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[{"name":"Kidney Health Research Collaborative, Department of Medicine, San Francisco Veterans Affairs Health Care System and University of California San Francisco (M.G.S., S.B.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-8155","authenticated-orcid":true,"given":"Jarett D.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas at Tyler Health Science Center (D.H., D.D., J.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-4208","authenticated-orcid":true,"given":"Simon B.","family":"Ascher","sequence":"additional","affiliation":[{"name":"Kidney Health Research Collaborative, Department of Medicine, San Francisco Veterans Affairs Health Care System and University of California San Francisco (M.G.S., S.B.A.)."},{"name":"Division of Hospital Medicine, University of California Davis, Sacramento (S.B.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4249"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004034.pub4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac584"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1708"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.005264"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30196-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu124"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316632364"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009041"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16092"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9085-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011652"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028410"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014659"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2022.0818"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.3187"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/37.3.323"},{"key":"e_1_3_3_23_2","unstructured":"Wechsler Adult Intelligence Scale. 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