{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T06:38:23Z","timestamp":1794638303731,"version":"4.9.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>In many practices, the screening for primary aldosteronism relies on a single-blood draw for plasma aldosterone concentration (PAC) and plasma renin activity (PRA) to establish an aldosterone-to-renin ratio (ARR). ARR levels vary between expert centers and repeated assays in the same individual, emphasizing the potential variability of this screening approach. A suppressed PRA to &lt;1 ng\/mL per h has been proposed as an alternative test to the ARR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We compared 2 potential screening approaches to identify probable primary aldosteronism (ARR\u226530 or ARR\u226520 versus PRA suppressed below 1 ng\/mL per h) in a cohort of 94\u2009829 paired PRA and PAC samples submitted by clinicians to evaluate the presence of primary aldosteronism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Of 94\u2009829 patients, 20.3% tested positive based on ARR\u226520 (95% CI, 20.0%\u201320.5%), 13.9% based on ARR\u226530 (95% CI, 13.6%\u201314.1%), versus 45.9% based on suppressed PRA (&lt;1 ng\/mL per minute [95% CI, 45.5%\u201346.2%]). In the PRA group, a range of aldosterone levels was observed: 5.5% had PAC &gt;15 ng\/dL, 25.2% had PAC 5 to 15 ng\/dL, and 15.2% had PAC &lt;5 ng\/dL, compared with 6%, 12.7%, and 1.6% in the ARR\u226520 group and 4.7%, 8.5%, and 0.7% in the ARR\u226530 group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In this cohort of individuals being screened for primary aldosteronism, substantially more individuals were identified using criteria focused on suppression of renin activity compared with using the aldosterone renin ratio as a screening tool.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.22884","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T09:00:44Z","timestamp":1721725244000},"page":"2072-2081","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Comparing ARR Versus Suppressed PRA as Screening Tests for Primary Aldosteronism"],"prefix":"10.1161","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2154-0176","authenticated-orcid":true,"given":"Marco","family":"Marcelli","sequence":"first","affiliation":[{"name":"Quest Diagnostics Nichols Institute, San Juan Capistrano, CA (M.M., C.B., M.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Bi","sequence":"additional","affiliation":[{"name":"Quest Diagnostics Nichols Institute, San Juan Capistrano, CA (M.M., C.B., M.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-7005","authenticated-orcid":true,"given":"John W.","family":"Funder","sequence":"additional","affiliation":[{"name":"Hudson Institute of Medical Research, Clayton, VIC, Australia (J.W.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"McPhaul","sequence":"additional","affiliation":[{"name":"Quest Diagnostics Nichols Institute, San Juan Capistrano, CA (M.M., C.B., M.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01476798"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0065"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0254"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/M20-4873"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18118"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001088"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab348"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18761"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16429"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.2003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30367-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08952"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpw001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.146449"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.251009"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa606"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvac049"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01041"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz150"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0030"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab924"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0073"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ21-0278"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0706"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.24455"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00753-6"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051081"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000350"},{"key":"e_1_3_3_31_2","first-page":"3","article-title":"Epidemiology of hypertension from childhood to young adulthood in black, white, and Hispanic population samples.","volume":"111","author":"Berenson GS","year":"1996","unstructured":"Berenson GS, Wattigney WA, Webber LS. Epidemiology of hypertension from childhood to young adulthood in black, white, and Hispanic population samples. Public Health Rep. 1996;111:3\u20136.","journal-title":"Public Health Rep"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000534"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.121665"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-00570-5"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213169"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110956"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.16029"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064318"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad024"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.20536"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ21-0508"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3803\/enm.2023.1789"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003513"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/HYPERTENSIONAHA.124.22884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T20:19:51Z","timestamp":1750796391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/HYPERTENSIONAHA.124.22884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1161\/HYPERTENSIONAHA.124.22884"],"URL":"https:\/\/doi.org\/10.1161\/hypertensionaha.124.22884","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}