{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:12:27Z","timestamp":1787807547597,"version":"build-2784847793"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>\n              Hypertensive disorders of pregnancy are associated with increased risk for cardiovascular disease, renal disease, and mortality. While the exact mechanisms remain unclear, T cells and reactive oxygen species have been implicated in its pathogenesis. We utilized Dahl salt-sensitive (SS), SS\n              <jats:sup>CD247\u2212\/\u2212<\/jats:sup>\n              (Dahl SS CD247 knockout rat; lacking T cells), and SS\n              <jats:sup>p67phox\u2212\/\u2212<\/jats:sup>\n              (Dahl SS p67\n              <jats:sup>phox<\/jats:sup>\n              [NOX2 (NADPH [nitcotinamide adenine dinucleotide phosphate] oxidase 2)] knockout rat; lacking NOX2) rats to investigate these mechanisms in primigravida and multigravida states.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              We assessed blood pressure and renal damage phenotypes in SS, SS\n              <jats:sup>CD247\u2212\/\u2212<\/jats:sup>\n              , and SS\n              <jats:sup>p67phox\u2212\/\u2212<\/jats:sup>\n              rats during primigravida and multigravida states. To investigate the contribution of NOX2 in T cells, we performed adoptive transfers of splenocytes or cluster of differentiation (CD)4\n              <jats:sup>+<\/jats:sup>\n              T cells from either SS or SS\n              <jats:sup>p67phox\u2212\/\u2212<\/jats:sup>\n              donors into SS\n              <jats:sup>CD247\u2212\/\u2212<\/jats:sup>\n              recipients to determine pregnancy-specific alterations in phenotype.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Multigravida SS rats developed significant pregnancy-induced renal damage and renal functional impairment associated with elevated maternal mortality rates, whereas deletion of T cells or NOX2 garnered protection. During primigravida states, this attenuation in renal damage was observed, with the greatest protection in the SS\n              <jats:sup>p67phox\u2212\/\u2212<\/jats:sup>\n              rat. To demonstrate that NOX2 in T cells contributes to adverse pregnancy phenotypes, adoptive transfer of SS splenocytes into SS\n              <jats:sup>CD247\u2212\/\u2212<\/jats:sup>\n              rats resulted in significant pregnancy-induced renal damage, whereas transfer of SS\n              <jats:sup>p67phox\u2212\/\u2212<\/jats:sup>\n              splenocytes garnered protection. Specifically, the transfer of SS CD4\n              <jats:sup>+<\/jats:sup>\n              T cells resulted in pregnancy-induced proteinuria and increases in uterine artery resistance index, an effect not seen with the transfer of SS\n              <jats:sup>p67phox\u2212\/\u2212<\/jats:sup>\n              CD4\n              <jats:sup>+<\/jats:sup>\n              T cells.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>T cells and NOX2-derived reactive oxygen species, thus, contribute to end-organ damage in both primigravida and multigravida pregnancies in the SS rat leading to increases in maternal mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.23303","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T09:00:32Z","timestamp":1726822832000},"page":"2357-2367","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats"],"prefix":"10.1161","volume":"81","author":[{"given":"John Henry","family":"Dasinger","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University (J.H.D., J.M.A.-B., S.D.W., E.C.B.-R., M.C.-S., K.E.B., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine M.","family":"Abais-Battad","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University (J.H.D., J.M.A.-B., S.D.W., E.C.B.-R., M.C.-S., K.E.B., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-2214","authenticated-orcid":true,"given":"Samuel D.","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University (J.H.D., J.M.A.-B., S.D.W., E.C.B.-R., M.C.-S., K.E.B., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C.","family":"Burns-Ray","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University (J.H.D., J.M.A.-B., S.D.W., E.C.B.-R., M.C.-S., K.E.B., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-6453","authenticated-orcid":true,"given":"Mary","family":"Cherian-Shaw","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University (J.H.D., J.M.A.-B., S.D.W., E.C.B.-R., M.C.-S., K.E.B., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn E.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University (J.H.D., J.M.A.-B., S.D.W., E.C.B.-R., M.C.-S., K.E.B., D.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-464X","authenticated-orcid":true,"given":"Daniel J.","family":"Fehrenbach","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis (D.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-0269","authenticated-orcid":true,"given":"David L.","family":"Mattson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta University (J.H.D., J.M.A.-B., S.D.W., E.C.B.-R., M.C.-S., K.E.B., 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