{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:37:50Z","timestamp":1793054270696,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Orthostatic hypertension is an emerging risk factor for adverse events. Recent consensus statements combine an increase in blood pressure upon standing with standing hypertension, but whether these 2 components have similar risk associations with cardiovascular disease (CVD) is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>The ARIC study (Atherosclerosis Risk in Communities) measured supine and standing blood pressure during visit 1 (1987\u20131989). We defined systolic orthostatic increase (a rise in systolic blood pressure [SBP] \u226520 mm\u2005Hg, standing minus supine blood pressure) and elevated standing SBP (standing SBP \u2265140 mm\u2005Hg) to examine the new consensus statement definition (rise in SBP \u226520 mm\u2005Hg and standing SBP \u2265140 mm\u2005Hg). We used Cox regression to examine associations with incident coronary heart disease, heart failure, stroke, fatal coronary heart disease, and all-cause mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Of 11\u2005369 participants (56% female; 25% Black adults; mean age, 54 years) without CVD at baseline, 1.8% had systolic orthostatic increases, 20.1% had standing SBP \u2265140 mm\u2005Hg, and 1.3% had systolic orthostatic increases with standing SBP \u2265140 mm\u2005Hg. During up to 30 years of follow-up, orthostatic increases were not significantly associated with any of the adverse outcomes of interest, while standing SBP \u2265140 mm\u2005Hg was significantly associated with all end points. In joint models comparing systolic orthostatic increases and standing SBP \u2265140 mm\u2005Hg, standing SBP \u2265140 mm\u2005Hg was significantly associated with a higher risk of CVD, and associations differed significantly from systolic orthostatic increases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Unlike systolic orthostatic increases, standing SBP \u2265140 mm\u2005Hg was strongly associated with CVD outcomes and death. These differences in CVD risk raise important concerns about combining systolic orthostatic increases and standing SBP \u2265140 mm\u2005Hg in a consensus definition for orthostatic hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.23409","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T10:02:01Z","timestamp":1733392921000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Orthostatic and Standing Hypertension and Risk of Cardiovascular Disease"],"prefix":"10.1161","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9008-0322","authenticated-orcid":true,"given":"Sean W.","family":"Dooley","sequence":"first","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.W.D., F.L.K., H.C., R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., L.A.L., M.Z., S.P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-632X","authenticated-orcid":true,"given":"Fredrick","family":"Larbi Kwapong","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.W.D., F.L.K., H.C., R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., L.A.L., M.Z., S.P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Col","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.W.D., F.L.K., H.C., R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., L.A.L., M.Z., S.P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-052X","authenticated-orcid":true,"given":"Ruth-Alma N.","family":"Turkson-Ocran","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.W.D., F.L.K., H.C., R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., L.A.L., M.Z., S.P.J.)."},{"name":"Harvard Medical School, Boston, MA (R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., M.Z., S.P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long H.","family":"Ngo","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.W.D., F.L.K., H.C., R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., L.A.L., M.Z., S.P.J.)."},{"name":"Harvard Medical School, Boston, MA (R.-A.N.T.-O., L.H.N., J.L.C., K.J.M., M.Z., S.P.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5744-1099","authenticated-orcid":true,"given":"Jennifer L.","family":"Cluett","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical 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