{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:10:22Z","timestamp":1791670222050,"version":"4.3.4"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Postural orthostatic tachycardia syndrome (POTS) is a frequently diagnosed cardiovascular disorder after COVID-19 infection. POTS is characterized by the presence of excessive sinus tachycardia on standing without a fall in blood pressure (BP). We investigated the BP profile using 24-hour ambulatory BP monitoring in patients with new-onset POTS after COVID-19 compared with prepandemic population-based controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We performed a case-control study in 100 patients (mean age, 40.0\u00b112.9 years; 85% women) with verified post\u2013COVID-19 new-onset POTS diagnosed by a positive head-up tilt testing versus 100 controls from a population-based cohort with a negative active standing test, no history of syncope, POTS, or endocrine disease (mean age, 42.3\u00b114.0 years; 78% women). Twenty-four-hour BP profile was assessed for circadian BP variation including hypotensive systolic BP (SBP) episodes (&lt;80, &lt;90, and &lt;100 mm\u2005Hg).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Patients with post\u2013COVID-19 POTS had significantly higher nighttime SBP, but not daytime SBP, and more daytime SBP hypotensive episodes compared with controls. Nondipping (34% versus 19%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and reverse dipping patterns (9% versus 0%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) were more frequent in post\u2013COVID-19 POTS. In the logistic regression, patients with post\u2013COVID-19 POTS had significantly higher mean 24-hour SBP (odds ratio, 1.08 [95% CI, 1.04\u20131.11];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and nighttime SBP (odds ratio, 1.07 [95% CI, 1.04\u20131.10];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), independent of age and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Patients with post\u2013COVID-19 POTS demonstrate higher mean 24-hour and nighttime SBP and show disruptions of circadian BP rhythm regulation compared with population-based controls, as well as more daytime hypotensive episodes. Future studies are needed to test whether patients with post\u2013COVID-19 POTS may benefit from tailored BP therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.23670","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T05:00:33Z","timestamp":1731301233000},"page":"2540-2548","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Blood Pressure Regulation in Post\u2013COVID POTS: Beyond Sinus Tachycardia"],"prefix":"10.1161","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9057-9148","authenticated-orcid":true,"given":"Madeleine","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden (M.J., F.R., V.H., P.M.N., A.F.)."},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden (M.J., V.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-6240","authenticated-orcid":true,"given":"Marcus","family":"St\u00e5hlberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institute, Stockholm, Sweden (M.S., C.L., A.F.)."},{"name":"Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden (M.S., C.L., A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-6623","authenticated-orcid":true,"given":"Fabrizio","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden (M.J., F.R., V.H., P.M.N., A.F.)."},{"name":"Department of Neuroscience, Imaging and Clinical Sciences, \u2018G.d\u2019Annunzio\u2019 University of Chieti-Pescara, Italy (F.R.)."},{"name":"Heart Department, \u2018SS Annunziata\u2019 Polyclinic University Hospital, Chieti, Italy (F.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lewinter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institute, Stockholm, Sweden (M.S., C.L., A.F.)."},{"name":"Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden (M.S., C.L., A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-0866","authenticated-orcid":true,"given":"Viktor","family":"Hamrefors","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden (M.J., F.R., V.H., P.M.N., A.F.)."},{"name":"Department of Cardiology, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden (M.J., V.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-8459","authenticated-orcid":true,"given":"Peter M.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department 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