{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:26:19Z","timestamp":1787235979270,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) risk differs across Asian subgroups, possibly due to differences in hypertension burden. We characterized lifetime blood pressure (BP) trajectories for East and South Asian individuals and compared their associations with CVD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Among 148\u2005872 UK Biobank participants with primary care utilization data, life course BP trajectories were fitted as a function of age by sex according to self-identified ethnicity. We determined associations of time-averaged young adulthood (18\u201339 years), middle age (40\u201364 years), and later life (\u226565 years) systolic BP (SBP) and diastolic BP with incident atherosclerotic CVD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The predicted SBP\/diastolic BP (95% CI) at age 30 years was 108 (103\u2013114)\/68 (65\u201371) mm\u2005Hg for East Asian and 114 (110\u2013118)\/72 (71\u201373) mm\u2005Hg for South Asian individuals. By age 40, South Asian individuals were projected to reach an SBP of 130.0 mm\u2005Hg, whereas East Asian individuals reached the equivalent SBP by age 49 years. Among South Asian individuals, each SD increase in young adulthood SBP was associated with a higher atherosclerotic CVD risk with an odds ratio (95% CI) of 1.41 (1.12\u20131.75), but not among East Asians (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.01). Midlife SBP was associated with peripheral artery disease among South Asian individuals (odds ratio, 2.08 [95% CI, 1.51\u20132.88]) and with ischemic stroke among East Asian individuals (odds ratio, 3.84 [95% CI, 1.08\u20135.07]). Later-life SBP was associated with myocardial infarction risk by 1.52 (1.15\u20131.92)-fold among South Asians and ischemic stroke by 2.50 (1.06\u20133.80)-fold among East Asian individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>East and South Asian individuals exhibit distinct BP trajectories that age-differentially associate with incident CVD. Disaggregating Asian subgroups may inform tailored hypertension screening and management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.23985","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T05:00:17Z","timestamp":1739336417000},"page":"520-531","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["East and South Asian-Specific Blood Pressure Trajectories and Cardiovascular Disease"],"prefix":"10.1161","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-3335","authenticated-orcid":true,"given":"So Mi J.","family":"Cho","sequence":"first","affiliation":[{"name":"Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.)."},{"name":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M.J.C., S.U., Y.R., A.B., S.G., W.E.H., R.B., M.C.H., P.N.)."},{"name":"Integrative Research Center for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea (S.M.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-9647","authenticated-orcid":true,"given":"Sarah","family":"Urbut","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.)."},{"name":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M.J.C., S.U., Y.R., A.B., S.G., W.E.H., R.B., M.C.H., P.N.)."},{"name":"Cardiology Division, Massachusetts General Hospital, Boston (S.U., R.B., M.C.H., P.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-8309","authenticated-orcid":true,"given":"Yunfeng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.)."},{"name":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M.J.C., S.U., Y.R., A.B., S.G., W.E.H., R.B., M.C.H., P.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarushi","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M.J.C., S.U., Y.R., A.B., S.G., W.E.H., R.B., M.C.H., 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