{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:21:08Z","timestamp":1794036068354,"version":"4.8.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Blood pressure (BP) time in target range (TTR) reflects the proportion of time that BP measurement is within a specified target range. We aim to summarize the evidence for relationships between TTR and adverse health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Seven databases were searched. After quality assessment and data extraction, meta-analyses were performed to generate pooled estimates of the association (hazard ratios) between TTR and health outcomes. Primary outcomes were all-cause mortality and cardiovascular death. Secondary outcomes included major adverse cardiovascular events, myocardial infarction, stroke, heart failure, atrial fibrillation, and adverse kidney events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>In all, 21 studies were included, mostly rated at low risk of bias. TTR was defined by systolic BP (SBP) in 15 studies and by both SBP and diastolic BP in 6 studies. Per SD increase of TTR was associated with significantly decreased risks of all-cause mortality (110\u2013130 mm\u2005Hg SBP TTR: hazard ratios, 0.85 [95% CI, 0.82\u20130.89]; 120\u2013140 mm\u2005Hg SBP TTR: 0.81 [95% CI, 0.70\u20130.94]; and 70\u201380 mm\u2005Hg diastolic BP TTR: 0.88 [95% CI, 0.83\u20130.93]), cardiovascular death (110\u2013130 mm\u2005Hg SBP TTR: 0.83 [95% CI, 0.78\u20130.87]; 120\u2013140 mm\u2005Hg SBP TTR: 0.76 [95% CI, 0.65\u20130.89]; and 70\u201380 mm\u2005Hg diastolic BP TTR: 0.85 [95% CI, 0.80\u20130.90]), major adverse cardiovascular events (120\u2013140 mm\u2005Hg SBP TTR: 0.76 [95% CI, 0.70\u20130.83]), and heart failure (110\u2013130 mm\u2005Hg SBP TTR: 0.84 [95% CI, 0.76\u20130.93] and 120\u2013140 mm\u2005Hg SBP TTR: 0.78 [95% CI, 0.68\u20130.89]). However, there was not sufficient support for the association of TTR with myocardial infarction, stroke, atrial fibrillation, or adverse kidney events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Higher TTR was associated with reduced risks of all-cause mortality, cardiovascular death, major adverse cardiovascular events, and heart failure, highlighting the importance of sustained BP control in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/\">https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:ext-link>\n                      ; Unique identifier: CRD42023486437.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.24013","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T05:00:27Z","timestamp":1736744427000},"page":"419-431","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Time in Target Range for Blood Pressure and Adverse Health Outcomes: A Systematic Review"],"prefix":"10.1161","volume":"82","author":[{"given":"Huairong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (H.W., J.S., Z.L., H.Y., K.W., X.Q., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (H.W., J.S., Z.L., H.Y., K.W., X.Q., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhike","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (H.W., J.S., Z.L., H.Y., K.W., X.Q., Y.W.)."},{"name":"Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China (Z.L., X.Q., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-4652","authenticated-orcid":true,"given":"Huan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (H.W., J.S., Z.L., H.Y., K.W., X.Q., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2690-3125","authenticated-orcid":true,"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (H.W., J.S., Z.L., H.Y., K.W., X.Q., Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3271-8618","authenticated-orcid":true,"given":"Xueying","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China (H.W., J.S., Z.L., H.Y., K.W., X.Q., Y.W.)."},{"name":"Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China (Z.L., X.Q., 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