{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:38:47Z","timestamp":1789162727132,"version":"build-2803163510"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Many medications can have blood pressure (BP)\u2013elevating effects, which might negatively impact BP control among people with hypertension. This study examines trends in prescription fills for BP-elevating and antihypertensive medications, individually and concurrently, among US individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Quarterly trends of individual and concurrent fills for BP-elevating and antihypertensive medications were reported using the nationwide sample from IQVIA\u2019s Total Patient Tracker database, covering 94% of all retail prescription fills in the United States. We identified 1387 products containing BP-elevating medications and 240 products containing antihypertensive medications. Percentage change from Q1\/2017 and average quarterly percent change from the joinpoint regression were used to present trends overall and by sex and age group (0\u201317, 18\u201344, 45\u201364, 65\u201374, and \u226575 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      From 2017 to 2023, fills remained stable for BP-elevating medications alone and increased for antihypertensive medications alone (9.5% increase; from 10.1% to 11.0%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Concurrent fills for antihypertensive and BP-elevating medications increased by 15.9% (from 5.4% to 6.2%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Fills for BP-elevating medications were higher among adult women compared with men; among women aged 18 to 44 years, this was primarily due to the use of combined oral contraceptives. In Q4\/2023, fills for BP-elevating medications were most common among those aged 65 to 74 years (women=30.7%; men=20.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>These results provide the first nationwide trends in concurrent prescription fills for BP-elevating and antihypertensive medications, indicating an increasing trend. Our findings might inform clinician decision-making regarding medication selection for patients with hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.24316","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T05:00:29Z","timestamp":1745298029000},"page":"1106-1115","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Blood Pressure\u2013Elevating and Antihypertensive Medication Prescription Trends"],"prefix":"10.1161","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6680-7235","authenticated-orcid":true,"given":"Ashutosh","family":"Kumar","sequence":"first","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (A.K., N.L.T., J.I.O., J.S.L., H.K.W., S.L.J.)."},{"name":"The Bizzell Group, New Carrollton, MD (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-0280","authenticated-orcid":true,"given":"Nicole L.","family":"Therrien","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (A.K., N.L.T., J.I.O., J.S.L., H.K.W., S.L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9340-3008","authenticated-orcid":true,"given":"John I.","family":"Ogwuegbu","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (A.K., N.L.T., J.I.O., J.S.L., H.K.W., S.L.J.)."},{"name":"Oak Ridge Institute for Science and Education, TN (J.I.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-6466","authenticated-orcid":true,"given":"Jun Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (A.K., N.L.T., J.I.O., J.S.L., H.K.W., S.L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-0706","authenticated-orcid":true,"given":"Hilary K.","family":"Wall","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (A.K., N.L.T., J.I.O., J.S.L., H.K.W., S.L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-5598","authenticated-orcid":true,"given":"John M.","family":"Flack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield (J.M.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4810-0572","authenticated-orcid":true,"given":"Sandra L.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (A.K., N.L.T., J.I.O., J.S.L., H.K.W., S.L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6735a4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.1326"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.0112"},{"key":"e_1_3_3_5_2","unstructured":"Centers for Disease Control and Prevention (CDC). 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