{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:04:44Z","timestamp":1788307484472,"version":"build-2803163510"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Hypertensive disorders of pregnancy (HDP), including gestational hypertension, preeclampsia, and eclampsia, contribute to increased maternal morbidity and mortality and long-term cardiovascular disease risk. It is unclear whether HDP arises from pregnancy-specific complications or preexisting maternal cardiovascular traits unmasked during pregnancy. This article evaluates whether cardiovascular health before pregnancy, assessed by the American Heart Association\u2019s Life\u2019s Essential 8 (LE8) score, is associated with HDP risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      The CARDIA (Coronary Artery Risk Development in Young Adults) is a longitudinal cohort study of 5115 Black and White men and women, aged 18 to 30 years at baseline (1985\u20131986), and followed for over 30 years (n\n                      <jats:sub>BlackWomen<\/jats:sub>\n                      =1480; n\n                      <jats:sub>WhiteWomen<\/jats:sub>\n                      =1307). The LE8 score (range, 0\u2013100) was calculated using health behaviors (diet, smoking, physical activity, sleep) and clinical metrics (body mass index, blood pressure, cholesterol, glucose). Cardiovascular health was categorized as low (LE8 &lt;50), moderate (LE8 50\u201379), or high (LE8 \u226580). HDP was self-reported as gestational hypertension, preeclampsia, or eclampsia in pregnancies lasting \u226523 weeks. Generalized mixed models assessed the association between LE8 and HDP among 2036 pregnancies from 1227 women, adjusting for age, time-varying parity, education, income, follow-up time, cumulative births, and multiple gestation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Mean baseline age was 24.1 years, 48.7% were Black women, and 19.9% reported HDP. Women with HDP had lower baseline LE8 scores (77.0 versus 79.5;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01). Compared with high cardiovascular health, moderate (odds ratio, 1.78 [95% CI, 1.13\u20132.81]) and low cardiovascular health (odds ratio, 3.95 [95% CI, 1.05\u201314.88]) were associated with increased HDP risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Lower prepregnancy cardiovascular health is an independent risk factor for HDP. Improving cardiovascular health may reduce HDP risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.124.24517","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T09:00:12Z","timestamp":1754643612000},"page":"1696-1704","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Lower Prepregnancy Cardiovascular Health is Associated With Hypertensive Disorders of Pregnancy: The CARDIA Study"],"prefix":"10.1161","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-8131","authenticated-orcid":true,"given":"Leah V.","family":"Dodds","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences (L.V.D., D.J.F.), University of Miami Miller School of Medicine, Miami, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-7460","authenticated-orcid":true,"given":"Daniel J.","family":"Feaster","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences (L.V.D., D.J.F.), University of Miami Miller School of Medicine, Miami, FL."},{"name":"Department of Biostatistics (D.J.F.), University of Miami Miller School of Medicine, Miami, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina I.","family":"Kiefe","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA (C.I.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-1964","authenticated-orcid":true,"given":"Erica P.","family":"Gunderson","sequence":"additional","affiliation":[{"name":"Bernard J Tyson Kaiser Permanente School of Medicine, Pasadena, CA (E.P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3257-3623","authenticated-orcid":true,"given":"Natalie A.","family":"Bello","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (N.A.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-9815","authenticated-orcid":true,"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Evelyn F. McKnight Brain Institute (T.R.), University of Miami Miller School of Medicine, Miami, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5561-7196","authenticated-orcid":true,"given":"Michael J.","family":"Paidas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences (M.P.), University of Miami Miller School of Medicine, Miami, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0966-7613","authenticated-orcid":true,"given":"Shathiyah","family":"Kulandavelu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Interdisciplinary Stem Cell Institute (S.K.), University of Miami Miller School of Medicine, Miami, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-7988","authenticated-orcid":true,"given":"Tali","family":"Elfassy","sequence":"additional","affiliation":[{"name":"Katz Family Division of Nephrology and Hypertension (T.E.), University of Miami Miller School of Medicine, Miami, FL."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.864"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004361"},{"key":"e_1_3_3_5_2","first-page":"56","volume-title":"Maternal mortality from preeclampsia\/eclampsia","author":"Ghulmiyyah L","year":"2012","unstructured":"Ghulmiyyah L, Sibai B. Maternal mortality from preeclampsia\/eclampsia. Elsevier. 2012:56\u201359."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313453"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9762-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2021.18"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.043"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/maj.0000000000000308"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061980"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39366.416817.be"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001124"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000582"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.118.009382"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001078"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.363"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(21)01299-2"},{"key":"e_1_3_3_21_2","first-page":"15","article-title":"A study of the reliability and comparative validity of the cardia dietary history.","volume":"4","author":"Liu K","year":"1994","unstructured":"Liu K, Slattery M, Jacobs D, Jr, Cutter G, McDonald A, Van Horn L, Hilner JE, Caan B, Bragg C, Dyer A, et al. A study of the reliability and comparative validity of the cardia dietary history. Ethn Dis. 1994;4:15\u201327.","journal-title":"Ethn Dis"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2020-001270"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(93)90087-k"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-198911000-00003"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2022.107291"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000000278"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318187a7b0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(90)90045-l"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.184101"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000740"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/28.6.137"},{"key":"e_1_3_3_32_2","first-page":"101","volume-title":"Enzymatic Methods for Quantification of Lipoprotein Lipids. Methods in Enzymology","author":"Warnick GR","year":"1986","unstructured":"Warnick GR. Enzymatic Methods for Quantification of Lipoprotein Lipids. Methods in Enzymology. Elsevier; 1986:101\u2013123."},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.10.3.430"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3414\/ME0468"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17084"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2023.2296366"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.020717"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.123.322001"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000005346"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.07.053"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12866"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.120.14875"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.8931"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18153"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070914"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01144-3"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa214"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100556"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101436"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smhs.2023.11.003"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.601"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.37.5.1209"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.043"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.02.016"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/reprodmed3010006"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000003762"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1177\/00333549141291s206"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2012.3740"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199911000-00022"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1080\/10641950701826695"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0b013e31818da09b"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2014.4953"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.6026\/973206300200116"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/HYPERTENSIONAHA.124.24517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:03:57Z","timestamp":1779300237000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/HYPERTENSIONAHA.124.24517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1161\/HYPERTENSIONAHA.124.24517"],"URL":"https:\/\/doi.org\/10.1161\/hypertensionaha.124.24517","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}