{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T18:49:45Z","timestamp":1782154185925,"version":"3.54.5"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>sFlt-1 (serum soluble fms-like tyrosine kinase-1) to PlGF (placental growth factor) can be used to predict the development of severe preeclampsia. The association between sFlt-1\/PlGF during pregnancy and long-term risk of hypertension is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This is a retrospective cohort study of patients enrolled from 2006 to 2008 in the ongoing LIFECODES biobank. Mean sFlt-1 and PlGF levels were collected in the second half of pregnancy. Electronic medical record review identified those who developed hypertension over 15 year follow-up. Adjusted Cox proportional hazard models were used to estimate hazard ratios and 95% CI for the time to diagnosis of hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the n=993 participants, n=260 (29.18%) were diagnosed with stage 1 and n=169 (17.0%) were diagnosed with stage 2 hypertension. One hundred thirteen of the participants in the database had a diagnosis of gestational hypertension or preeclampsia. A history of preeclampsia or a history of gestational hypertension was both significantly associated with developing hypertension later in life, with adjusted hazard ratios of 2.17 (95% CI, 1.44\u20133.28) and 3.50 (95% CI, 2.21\u20135.54), respectively. We observed no significant association between the hazard of developing hypertension and sFlt-1\/PlGF. However, mean PlGF levels in those who remained normotensive in the follow-up were significantly higher, 546.7 pg\/mL (SD=369.5), compared with those who developed hypertension, 513.7 pg\/mL (SD=389.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>A history of hypertensive disease of pregnancy was significantly associated with the hazard of developing HTN later in life, while elevated sFlt-1\/PlGF levels were not. PlGF levels alone were significantly lower in those who developed hypertension later.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/hypertensionaha.125.25552","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:00:36Z","timestamp":1775552436000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Obstetric History Versus Biomarkers: Hypertension Risk Up to 15 Years Postpartum"],"prefix":"10.1161","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-1480","authenticated-orcid":true,"given":"Tooba Z.","family":"Anwer","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine (T.Z.A., T.F.M.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Cantonwine","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. 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