{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:53:25Z","timestamp":1791208405378,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2012,9,26]]},"abstract":"\n Background<\/jats:title>\n \n Atherosclerotic abdominal aortic aneurysm (\n AAA<\/jats:styled-content>\n ) is a progressive, gradual aortic rupture that results in death in the absence of surgical intervention. Key factors that regulate initiation and progression of\n AAA<\/jats:styled-content>\n are unknown, making targeted interventions difficult. Micro\n RNA<\/jats:styled-content>\n s play a fundamental role in atherosclerosis, and atherosclerotic coronary artery disease is characterized by tissue\u2010 and plasma\u2010specific micro\n RNA<\/jats:styled-content>\n signatures. However, little is known about micro\n RNA<\/jats:styled-content>\n s involved in\n AAA<\/jats:styled-content>\n pathology. This study examined tissue and plasma micro\n RNA<\/jats:styled-content>\n s specifically associated with\n AAA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n AAA<\/jats:styled-content>\n and normal wall tissues were sampled from patients undergoing\n AAA<\/jats:styled-content>\n repair (n=13; mean age, 68\u00b16 years) and aortic valve replacement surgery (n=7; mean age, 66\u00b14 years), respectively. Micro\n RNA<\/jats:styled-content>\n expression was assessed by high\u2010throughput micro\n RNA<\/jats:styled-content>\n arrays and validated by real\u2010time polymerase chain reaction for individual micro\n RNA<\/jats:styled-content>\n s that showed significant expression differences in the initial screening. Micro\n RNA<\/jats:styled-content>\n s related to fibrosis (miR\u201029b), inflammation (miR\u2010124a, miR\u2010146a, miR\u2010155, and miR\u2010223), and endothelium (miR\u2010126, let\u20107 family members, and miR\u201021) were significantly upregulated in\n AAA<\/jats:styled-content>\n tissue. Significant negative correlations were seen in expression levels of monocyte chemoattractant protein\u20101 and miR\u2010124a, \u2010146a, and \u2010223; tumor necrosis factor\u2010\u03b1 and miR\u2010126 and \u2010223; and transforming growth factor\u2010\u03b2 and miR\u2010146a. Expression of micro\n RNA<\/jats:styled-content>\n s, such as miR\u201029b, miR\u2010124a, miR\u2010155, and miR\u2010223, that were upregulated in\n AAA<\/jats:styled-content>\n tissue was significantly reduced in plasma of patients with\n AAA<\/jats:styled-content>\n (n=23; mean age, 72\u00b19 years) compared to healthy controls (n=12; mean age, 51\u00b111 years) and patients with coronary artery disease (n=17; mean age, 71\u00b19 years).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The expression of some micro\n RNA<\/jats:styled-content>\n s was specifically upregulated in\n AAA<\/jats:styled-content>\n tissue, warranting further studies on the micro\n RNA<\/jats:styled-content>\n function in\n AAA<\/jats:styled-content>\n pathogenesis and on the possibility of using a micro\n RNA<\/jats:styled-content>\n biomarker for\n AAA<\/jats:styled-content>\n diagnosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.112.000745","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T16:46:06Z","timestamp":1369413966000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":138,"title":["Tissue\u2010 and Plasma\u2010Specific MicroRNA Signatures for Atherosclerotic Abdominal Aortic Aneurysm"],"prefix":"10.1161","volume":"1","author":[{"given":"Keiwa","family":"Kin","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satsuki","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitoshi","family":"Shirakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Torikai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Daimon","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Laboratory of RNA Function, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kuratani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33099"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06607"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn156"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.106.141986"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq013"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0637"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2010.11.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1997.10473627"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200810425"},{"key":"e_1_3_2_12_2","unstructured":"R Development Core Team . 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