{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:33:25Z","timestamp":1790264005645,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2013,1,23]]},"abstract":"\n Background<\/jats:title>\n \n Although the heritability of atrial fibrillation\/atrial flutter (\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l in multiplex families.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We examined the familial risk of\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76\u00a0years with Hospital Discharge Register data for 1987\u20132008 and Outpatient Register data for 2001\u20132008 to compare\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l risk among relatives of all 300\u00a0586 individuals with\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases and controls. Parents (odds ratio [\n OR<\/jats:styled-content>\n ] 1.95 [95% CI 1.89 to 2.00]) and siblings (\n OR<\/jats:styled-content>\n =3.08 [3.00 to 3.16]) of cases had higher odds of\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l than did parents and siblings of controls.\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l\n OR<\/jats:styled-content>\n s were increased in both sexes. For 2% of cases, both parents had\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l, compared with only 0.7% of controls (\n OR<\/jats:styled-content>\n =3.60 [3.30 to 3.92]). Moreover, 3% of cases had \u22652 siblings with\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l, compared with 1% of controls (\n OR<\/jats:styled-content>\n =5.72 [5.28 to 6.19]). In premature cases (diagnosed at age <50\u00a0years), the\n OR<\/jats:styled-content>\n s were 5.04 (4.36 to 5.82) and 8.51 (6.49 to 11.15) for\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l in both parents and\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l in \u22652 siblings, respectively. The overall spouse\n OR<\/jats:styled-content>\n was 1.16 (1.13 to 1.19).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Family history of\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l increases the odds of\n AF<\/jats:styled-content>\n \/\n AF<\/jats:styled-content>\n l in first\u2010degree relatives. High familial risks were observed in multiplex families.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.112.003384","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T16:49:11Z","timestamp":1369414151000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["High Familial Risk of Atrial Fibrillation\/Atrial Flutter in Multiplex Families: A Nationwide Family Study in Sweden"],"prefix":"10.1161","volume":"2","author":[{"given":"Bengt","family":"Z\u00f6ller","sequence":"first","affiliation":[{"name":"Center for Primary Health Care Research, Region Sk\u00e5ne\/Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Region Sk\u00e5ne\/Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Region Sk\u00e5ne\/Lund University, Malm\u00f6, Sweden"},{"name":"Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Region Sk\u00e5ne\/Lund University, Malm\u00f6, Sweden"},{"name":"Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318224b037"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194309022291002"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00465-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.23.2851"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-0034-8"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi727"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.02.016"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01126.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.786665"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.4130"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1690"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703273361302"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06007"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.417"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.416"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.537"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46315"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2011.07.027"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq348"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.779181"},{"key":"e_1_3_4_22_2","first-page":"361","article-title":"Multiplex families with two or more probands","volume":"20","author":"Morton NE","year":"1968","unstructured":"Morton NE, Mi MP. Multiplex families with two or more probands. Am J Hum Genet. 1968;20:361\u2013367.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_4_23_2","first-page":"733","article-title":"The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches","volume":"10","author":"Risch N","year":"2001","unstructured":"Risch N. The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol Biomarkers Prev. 2001;10:733\u2013741.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199231034.001.0001"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2005.06.015"},{"key":"e_1_3_4_26_2","first-page":"47","article-title":"[Familial manifestation of idiopathic atrial flutter]","volume":"140","author":"Gillor A","year":"1992","unstructured":"Gillor A, Korsch E. [Familial manifestation of idiopathic atrial flutter]. Monatsschr Kinderheilkd. 1992;140:47\u201350.","journal-title":"Monatsschr Kinderheilkd"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-26577-1_5"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.959882"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60072-6"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9404-1"},{"key":"e_1_3_4_32_2","volume-title":"Modern Epidemiology","author":"Rothman K","year":"2008","unstructured":"Rothman K, Greenland S. Modern Epidemiology. 3rd ed. Philadelphia, PA: Lippincott\u2010Raven, 2008.","edition":"3"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e32833a1947"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.03.038"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp076"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114842"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.039677"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.112920"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.112.003384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:44:34Z","timestamp":1715597074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.112.003384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,23]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,23]]}},"alternative-id":["10.1161\/JAHA.112.003384"],"URL":"https:\/\/doi.org\/10.1161\/jaha.112.003384","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,23]]},"assertion":[{"value":"2012-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003384"}}