{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:40:36Z","timestamp":1792082436856,"version":"4.4.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2012,11,29]]},"abstract":"\n Background<\/jats:title>\n \n Implantable cardioverter\u2010defibrillators (\n ICD<\/jats:styled-content>\n s) are placed in patients at risk for sudden cardiac death, but the procedure may cause adverse events. Patient body habitus may be an important factor responsible for\n ICD<\/jats:styled-content>\n implantation complications. We assessed whether underweight or obese compared with normal weight patients, as defined by body mass index (\n BMI<\/jats:styled-content>\n ), were at increased risk for adverse events from\n ICD<\/jats:styled-content>\n implantation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We studied 83\u00a0312 first\u2010time\n ICD<\/jats:styled-content>\n recipients in the\n N<\/jats:styled-content>\n ational\n C<\/jats:styled-content>\n ardiovascular\n D<\/jats:styled-content>\n ata\n R<\/jats:styled-content>\n egistry\u2010\n ICD<\/jats:styled-content>\n Registry implanted between April 2010 and June 2011. Using hierarchical multivariable logistic regression adjusted for patient demographic and clinical characteristics, we examined the association of\n BMI<\/jats:styled-content>\n with in\u2010hospital complications, length of hospital stay, and mortality. Underweight (\n BMI<\/jats:styled-content>\n \u226418.5\u00a0kg\/m\n 2<\/jats:sup>\n ) patients comprised 1.7% of the cohort (n=1434), whereas obese (\n BMI<\/jats:styled-content>\n \u226530\u00a0kg\/m\n 2<\/jats:sup>\n ) patients comprised 40.1% (n=33\u00a0339). Overall, a higher proportion of underweight patients experienced complications (normal weight, 2.3%; obese, 2.1%; underweight 5.2%;\n P<\/jats:italic>\n <0.0001) and death (normal weight, 0.3%; obese, 0.3%; underweight 0.8%;\n P<\/jats:italic>\n =0.026) as a result of\n ICD<\/jats:styled-content>\n implantation. After multivariable adjustment, underweight\n ICD<\/jats:styled-content>\n recipients had a greater odds of complications (odds ratio [\n OR<\/jats:styled-content>\n ], 2.15; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 1.68 to 2.75;\n P<\/jats:italic>\n <0.0001), hospital stay >3\u00a0days (\n OR<\/jats:styled-content>\n , 1.62; 95%\n CI<\/jats:styled-content>\n , 1.38 to 1.89;\n P<\/jats:italic>\n <0.0001), and in\u2010hospital death (\n OR<\/jats:styled-content>\n , 2.27; 95%\n CI<\/jats:styled-content>\n , 1.21 to 4.27;\n P<\/jats:italic>\n =0.011) compared with normal weight patients. Obese patients did not exhibit any meaningful differences in the same outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In a large, real\u2010world population, underweight first\u2010time\n ICD<\/jats:styled-content>\n recipients experienced significantly more periprocedural complications, prolonged hospital stays, and in\u2010hospital death compared with normal weight patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.112.003863","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T16:46:09Z","timestamp":1369413969000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Low Body Mass Index but Not Obesity Is Associated With In\u2010Hospital Adverse Events and Mortality Among Implantable Cardioverter\u2010Defibrillator Recipients: Insights From the National Cardiovascular Data Registry"],"prefix":"10.1161","volume":"1","author":[{"given":"Jonathan C.","family":"Hsu","sequence":"first","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Varosy","sequence":"additional","affiliation":[{"name":"VA Eastern Colorado Health Care System, University of Colorado, and the Colorado Cardiovascular Outcomes Research (CCOR) Group, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikun","family":"Bao","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeptha P.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800541"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.7.898"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033088"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00777-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50251.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70056-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.07.015"},{"key":"e_1_3_3_11_2","first-page":"1","article-title":"Physical status: the use and interpretation of anthropometry. 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World Health Organ Tech Rep Ser. 2000;894:i\u2013xii, 1\u2013253.","journal-title":"World Health Organ Tech Rep Ser."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2003.23"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum113"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.014"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02674.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp194"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.777888"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.112.003863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:17:53Z","timestamp":1715595473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.112.003863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11,29]]}},"alternative-id":["10.1161\/JAHA.112.003863"],"URL":"https:\/\/doi.org\/10.1161\/jaha.112.003863","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]},"assertion":[{"value":"2012-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003863"}}