{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:08Z","timestamp":1787836808035,"version":"build-2784847793"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2013,8,22]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              It is difficult to accurately determine prognosis of patients with hypertension and chronic stable coronary artery disease (\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              ). Our aim was to construct a risk score for predicting important adverse events in this population.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with hypertension and chronic stable\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              enrolled in the\n              <jats:styled-content style=\"fixed-case\">IN<\/jats:styled-content>\n              ternational\n              <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>\n              rapamil\u2010\n              <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\n              \/Trandolapril\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              udy (\n              <jats:styled-content style=\"fixed-case\">INVEST<\/jats:styled-content>\n              ) comprised the study cohort. Candidate predictor variables were obtained from patients with at least 1 postbaseline visit. Patients were divided into development (n=18\u00a0484) and validation cohorts (n=2054). Cox regression model identified predictors of the primary outcome: all\u2010cause mortality, myocardial infarction, or stroke at a mean follow\u2010up of 2.3\u00a0years. The hazard ratio of each variable was rounded to the nearest integer to construct score weights. A score 0 to 4 defined low\u2010risk, 5 to 6 intermediate\u2010risk and \u22657 high\u2010risk. The following variables were retained in the final model: age, residence, body mass index, on\u2010treatment heart rate and BP, prior myocardial infarction, heart failure, stroke\/transient ischemic attack, smoking, diabetes, peripheral arterial disease, and chronic kidney disease. The primary outcome occurred in 2.9% of the low\u2010risk group, 6.5% of the intermediate\u2010risk group, and 18.0% of the high\u2010risk group (\n              <jats:italic>P<\/jats:italic>\n              for trend &lt;0.0001). The model was good at discriminating those who had an event versus those who did not (C\u2010statistic=0.75). The model performed well in a validation cohort (C\u2010statistic=0.77).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Readily available clinical variables can rapidly stratify patients with hypertension and chronic stable\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              into useful risk categories.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.113.000205","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T02:45:06Z","timestamp":1376621106000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Simple Integer Risk Score to Determine Prognosis of Patients With Hypertension and Chronic Stable Coronary Artery Disease"],"prefix":"10.1161","volume":"2","author":[{"given":"Anthony A.","family":"Bavry","sequence":"first","affiliation":[{"name":"College of Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharam J.","family":"Kumbhani","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen M.","family":"Handberg","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda M.","family":"Cooper\u2010DeHoff","sequence":"additional","affiliation":[{"name":"College of Medicine, University of 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