{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:48:04Z","timestamp":1790772484219,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,1,27]]},"abstract":"<jats:sec xml:lang=\"en\"><jats:title>Background<\/jats:title><jats:p xml:lang=\"en\">Systemic hypertension is a common characteristic in acute heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>). This increasingly recognized phenotype is commonly associated with renal dysfunction and there is an unmet need for renal enhancing therapies. In a canine model of<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>and acute vasoconstrictive hypertension we characterized and compared the cardiorenal actions of<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010atrial natriuretic peptide (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>), a novel particulate guanylyl cyclase (pGC) activator, and nitroglycerin, a soluble guanylyl cyclase (<jats:styled-content style=\"fixed-case\">sGC<\/jats:styled-content>) activator.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Methods and Results<\/jats:title><jats:p xml:lang=\"en\"><jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>was induced by rapid RV pacing (180\u00a0beats per minute) for 10\u00a0days. On day 11, hypertension was induced by continuous angiotensin II infusion. We characterized the cardiorenal and humoral actions prior to, during, and following intravenous<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>(n=7), nitroglycerin (n=7), and vehicle (n=7) infusion. Mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) was reduced by<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>(139\u00b14 to 118\u00b13\u00a0mm\u00a0Hg,<jats:italic>P<\/jats:italic>&lt;0.05) and nitroglycerin (137\u00b13 to 116\u00b14\u00a0mm\u00a0Hg,<jats:italic>P<\/jats:italic>&lt;0.05); similar findings were recorded for pulmonary wedge pressure (<jats:styled-content style=\"fixed-case\">PCWP<\/jats:styled-content>) with<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>(12\u00b12 to 6\u00b12\u00a0mm\u00a0Hg,<jats:italic>P<\/jats:italic>&lt;0.05) and nitroglycerin (12\u00b11 to 6\u00b11\u00a0mm\u00a0Hg,<jats:italic>P<\/jats:italic>&lt;0.05).<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>enhanced renal function with significant increases (<jats:italic>P<\/jats:italic>&lt;0.05) in glomerular filtration rate (38\u00b14 to 53\u00b15\u00a0mL\/min), renal blood flow (132\u00b118 to 236\u00b123\u00a0mL\/min), and natriuresis (11\u00b14 to 689\u00b137\u00a0mEq\/min) and also inhibited aldosterone activation (32\u00b13 to 23\u00b12\u00a0ng\/dL,<jats:italic>P<\/jats:italic>&lt;0.05), whereas nitroglycerin had no significant (<jats:italic>P<\/jats:italic>&gt;0.05) effects on these renal parameters or aldosterone activation.<\/jats:p><\/jats:sec><jats:sec xml:lang=\"en\"><jats:title>Conclusions<\/jats:title><jats:p xml:lang=\"en\">Our results advance the differential cardiorenal actions of<jats:styled-content style=\"fixed-case\">pGC<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>) and<jats:styled-content style=\"fixed-case\">sGC<\/jats:styled-content>(nitroglycerin) mediated<jats:styled-content style=\"fixed-case\">cGMP<\/jats:styled-content>activation. These distinct renal and aldosterone modulating actions make<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ANP<\/jats:styled-content>an attractive therapeutic for<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>with concomitant hypertension, where renal protection is a key therapeutic goal.<\/jats:p><\/jats:sec>","DOI":"10.1161\/jaha.113.000206","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T01:45:08Z","timestamp":1388713508000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["M\u2010Atrial Natriuretic Peptide and Nitroglycerin in a Canine Model of Experimental Acute Hypertensive Heart Failure: Differential Actions of 2 cGMP Activating Therapeutics"],"prefix":"10.1161","volume":"3","author":[{"given":"Paul M.","family":"McKie","sequence":"first","affiliation":[{"name":"Cardiorenal Research Laboratory, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cataliotti","sequence":"additional","affiliation":[{"name":"Cardiorenal Research Laboratory, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Ichiki","sequence":"additional","affiliation":[{"name":"Cardiorenal Research Laboratory, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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