{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:09:47Z","timestamp":1791137387289,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2013,11,18]]},"abstract":"\n Background<\/jats:title>\n \n The prevalence and significance of low normal and abnormal ankle brachial index (\n ABI<\/jats:styled-content>\n ) values in a community\u2010dwelling population of sedentary, older individuals is unknown. We describe the prevalence of categories of definite peripheral artery disease (\n PAD<\/jats:styled-content>\n ), borderline\n ABI<\/jats:styled-content>\n , low normal\n ABI,<\/jats:styled-content>\n and no\n PAD<\/jats:styled-content>\n and their association with lower\u2010extremity functional performance in the\n LIFE<\/jats:styled-content>\n Study population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Participants age 70 to 89 in the\n LIFE<\/jats:styled-content>\n Study underwent baseline measurement of the\n ABI<\/jats:styled-content>\n , 400\u2010m walk, and 4\u2010m walking velocity. Participants were classified as follows: definite\n PAD<\/jats:styled-content>\n (\n ABI<\/jats:styled-content>\n <0.90), borderline\n PAD<\/jats:styled-content>\n (\n ABI<\/jats:styled-content>\n 0.90 to 0.99), low normal\n ABI<\/jats:styled-content>\n (\n ABI<\/jats:styled-content>\n 1.00 to 1.09), and no\n PAD<\/jats:styled-content>\n (\n ABI<\/jats:styled-content>\n 1.10 to 1.40). Of 1566 participants, 220 (14%) had definite\n PAD<\/jats:styled-content>\n , 250 (16%) had borderline\n PAD<\/jats:styled-content>\n , 509 (33%) had low normal\n ABI<\/jats:styled-content>\n , and 587 (37%) had no\n PAD<\/jats:styled-content>\n . Among those with definite\n PAD<\/jats:styled-content>\n , 65% were asymptomatic. Adjusting for age, sex, race, body mass index, smoking, and comorbidities, lower\n ABI<\/jats:styled-content>\n was associated with longer mean 400\u2010m walk time: (definite\n PAD<\/jats:styled-content>\n =533\u00a0seconds; borderline\n PAD<\/jats:styled-content>\n =514\u00a0seconds; low normal\n ABI<\/jats:styled-content>\n =503\u00a0seconds; and no\n PAD<\/jats:styled-content>\n =498\u00a0seconds [\n P<\/jats:italic>\n <0.001]). Among asymptomatic participants with and without\n PAD<\/jats:styled-content>\n , lower\n ABI<\/jats:styled-content>\n values were also associated with longer 400\u2010m walk time (\n P<\/jats:italic>\n <0.001) and slower walking velocity (\n P<\/jats:italic>\n =0.042).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Among older community\u2010dwelling men and women, 14% had\n PAD<\/jats:styled-content>\n and 49% had borderline or low normal\n ABI<\/jats:styled-content>\n values. Lower\n ABI<\/jats:styled-content>\n values were associated with greater functional impairment, suggesting that lower extremity atherosclerosis may be a common preventable cause of functional limitations in older people.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL:\n http:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n Unique identifier: NCT01072500.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.113.000257","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T03:38:45Z","timestamp":1384313925000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Ankle Brachial Index Values, Leg Symptoms, and Functional Performance Among Community\u2010Dwelling Older Men and Women in the Lifestyle Interventions and Independence for Elders Study"],"prefix":"10.1161","volume":"2","author":[{"given":"Mary M.","family":"McDermott","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Applegate","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise E.","family":"Bonds","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Buford","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Church","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Espeland","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Yale School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Haskell","sequence":"additional","affiliation":[{"name":"Stanford University, Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Lovato","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston\u2010Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran F.","family":"Reid","sequence":"additional","affiliation":[{"name":"Tufts University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Newman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, 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