{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:53Z","timestamp":1787018093477,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2013,9,26]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The adipocyte\u2010derived hormone leptin is elevated in obesity and may contribute to vascular risk associated with obesity. The mechanism(s) by which leptin affects vascular disease is unclear, although leptin has been shown to increase sympathetic activity. The aim of this study was to investigate the effect of leptin treatment on endothelial function and the role of the local sympathetic nervous system in mediating these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Recombinant leptin was administered to C57BL6\/J mice every other day for 1\u00a0week. Mesenteric arteriole myography revealed that leptin treatment caused significant impairment of endothelium\u2010dependent vasorelaxation. Although leptin alone did not raise aortic blood pressure, leptin treatment augmented the blood pressure response to angiotensin II. The effects of leptin on mesenteric arteriolar function and aortic blood pressure response to angiotensin II were neutralized following sympathetic denervation to the mesenteric vasculature. The superoxide scavenger\n                      <jats:styled-content style=\"fixed-case\">TEMPOL<\/jats:styled-content>\n                      was also effective in preventing the effects of leptin on endothelial dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Leptin causes endothelial dysfunction and enhances the effects of angiotensin II on blood pressure. These effects of leptin are mediated by sympathetic nervous system activation and superoxide and may contribute to vascular stiffness and hypertension in obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.113.000299","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T20:17:27Z","timestamp":1379362647000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Leptin\u2010Induced Endothelial Dysfunction Is Mediated by Sympathetic Nervous System Activity"],"prefix":"10.1161","volume":"2","author":[{"given":"Jintao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. E.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Eitzman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068177"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/381745a0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.13.1706"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13143"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.25.8.1634"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119532"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc5001.101061"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000105904.02142.e7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000096394.32433.E9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000252068.89775.ee"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2012.29"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2012"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.09.029"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.090696"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0162"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.218404"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.815803"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-10-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-06-0662"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm633"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411204"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624776"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624777"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05623.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.4.903"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.6.2382"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.293"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.128"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.02.012"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3005"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.096053"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409530102"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10351"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00852.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803767"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04132.x"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01953.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21069"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1139\/y11-084"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.10.1231"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.034"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62039-9"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.113.000299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:49:31Z","timestamp":1715582971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.113.000299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,26]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9,26]]}},"alternative-id":["10.1161\/JAHA.113.000299"],"URL":"https:\/\/doi.org\/10.1161\/jaha.113.000299","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,26]]},"assertion":[{"value":"2013-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e000299"}}