{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:52:56Z","timestamp":1790484776452,"version":"4.1.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2013,9,26]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Consumption of tuna or other broiled or baked fish, but not fried fish, is associated with fewer subclinical brain abnormalities on magnetic resonance imaging (\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              ). We investigated the association between plasma phospholipid omega\u20103 polyunsaturated fatty acids (\n              <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\n              s), objective biomarkers of exposure, and subclinical brain abnormalities on\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In the community\u2010based\n              <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n              ardiovascular\n              <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n              ealth\n              <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n              tudy, 3660 participants aged \u226565 underwent brain\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              in 1992\u20131994, and 2313 were rescanned 5\u00a0years later.\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              s were centrally read by neuroradiologists in a standardized, blinded manner. Participants with recognized transient ischemic attacks or stroke were excluded. Phospholipid\n              <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\n              s were measured in stored plasma collected in 1992\u20131993 and related to cross\u2010sectional and longitudinal\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              findings. After multivariable adjustment, the odds ratio for having a prevalent subclinical infarct was 0.60 (95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              , 0.44 to 0.82;\n              <jats:italic>P<\/jats:italic>\n              for trend=0.001) in the highest versus lowest long\u2010chain omega\u20103\n              <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\n              quartile. Higher long\u2010chain omega\u20103\n              <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\n              content was also associated with better white matter grade, but not with sulcal or ventricular grades, markers of brain atrophy, or with incident subclinical infarcts. The phospholipid intermediate\u2010chain omega\u20103\n              <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\n              alpha\u2010linolenic acid was associated only with modestly better sulcal and ventricular grades. However, this finding was not supported in the analyses with alpha\u2010linolenic acid intake.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among older adults, higher phospholipid long\u2010chain omega\u20103\n              <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\n              content was associated with lower prevalence of subclinical infarcts and better white matter grade on\n              <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n              . Our results support the beneficial effects of fish consumption, the major source of long\u2010chain omega\u20103\n              <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\n              s, on brain health in later life. The role of plant\u2010derived alpha\u2010linolenic acid in brain health requires further investigation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.113.000305","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T15:27:10Z","timestamp":1381505230000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Circulating Omega\u20103 Polyunsaturated Fatty Acids and Subclinical Brain Abnormalities on MRI in Older Adults: The Cardiovascular Health Study"],"prefix":"10.1161","volume":"2","author":[{"given":"Jyrki K.","family":"Virtanen","sequence":"first","affiliation":[{"name":"University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Siscovick","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, University of Washington, Seattle, WA"},{"name":"Department of Epidemiology, University of Washington, Seattle, WA"},{"name":"Department of Medicine, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozenn N.","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, University of Washington, Seattle, WA"},{"name":"Department of Medicine, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"William T.","family":"Longstreth","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, University of Washington, Seattle, WA"},{"name":"Department of Epidemiology, University of Washington, Seattle, WA"},{"name":"Department of Medicine, University of Washington, Seattle, WA"},{"name":"Department of Neurology, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Spiegelman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard School of Public Health, Boston, MA"},{"name":"Department of Biostatistics, Harvard School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B.","family":"Rimm","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"},{"name":"Department of Nutrition, Harvard School of Public Health, Boston, MA"},{"name":"Department of Epidemiology, Harvard School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena B.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of New Mexico, Albuquerque, 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