{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:12:31Z","timestamp":1769742751499,"version":"3.49.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,1,27]]},"abstract":"\n Background<\/jats:title>\n \n Pulmonary hypertension (\n PH<\/jats:styled-content>\n ) in patients with heart failure (\n HF<\/jats:styled-content>\n ) is associated with worse outcomes and is rapidly being recognized as a therapeutic target. To facilitate pragmatic research efforts, data regarding the prognostic importance of noninvasively assessed pulmonary artery systolic pressure (\n PASP<\/jats:styled-content>\n ) in stable ambulatory patients with\n HF<\/jats:styled-content>\n are needed.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We examined the association between echocardiographic\n PASP<\/jats:styled-content>\n and outcomes in 417 outpatients with\n HF<\/jats:styled-content>\n (age, 54\u00b113\u00a0years; 60.7% men; 50.4% whites; 24.9% with preserved ejection fraction). Median\n PASP<\/jats:styled-content>\n was 36\u00a0mm\u00a0Hg (interquartile range [\n IQR<\/jats:styled-content>\n ]: 29, 46). After a median follow\u2010up of 2.6\u00a0years (\n IQR<\/jats:styled-content>\n : 1.7, 3.9) there were 72 major events (57 deaths; 9 urgent heart transplants; and 6 ventricular assist device implantations) and 431 hospitalizations for\n HF<\/jats:styled-content>\n . In models adjusting for clinical risk factors and therapy, a 10\u2010mm\u00a0Hg higher\n PASP<\/jats:styled-content>\n was associated with 37% higher risk (95%\n CI<\/jats:styled-content>\n : 18, 59;\n P<\/jats:italic>\n <0.001) for major events, and 11% higher risk (95%\n CI<\/jats:styled-content>\n : 1, 23;\n P<\/jats:italic>\n =0.039) for major events or\n HF<\/jats:styled-content>\n hospitalization. The threshold that maximized the likelihood ratio for both endpoints was 48\u00a0mm\u00a0Hg; those with\n PASP<\/jats:styled-content>\n \u226548\u00a0mm\u00a0Hg (N=84; 20.1%) had an adjusted hazard ratio of 3.33 (95%\n CI<\/jats:styled-content>\n : 1.96, 5.65;\n P<\/jats:italic>\n <0.001) for major events and 1.47 (95%\n CI<\/jats:styled-content>\n : 1.02, 2.11;\n P<\/jats:italic>\n =0.037) for major events or\n HF<\/jats:styled-content>\n hospitalization. Reduced right ventricular systolic function had independent prognostic utility over\n PASP<\/jats:styled-content>\n for adverse outcomes. Right atrial pressure and transtricuspid gradient both contributed to risk.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Elevated\n PASP<\/jats:styled-content>\n , determined by echocardiography, identifies ambulatory patients with\n HF<\/jats:styled-content>\n at increased risk for adverse events.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.113.000363","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T06:29:49Z","timestamp":1391495389000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Echocardiographic Assessment of Pulmonary Artery Systolic Pressure and Outcomes in Ambulatory Heart Failure Patients"],"prefix":"10.1161","volume":"3","author":[{"given":"Andreas P.","family":"Kalogeropoulos","sequence":"first","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarawut","family":"Siwamogsatham","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, GA"},{"name":"Faculty of Medicine, Chulalongkorn University & King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Hayek","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan","family":"Deka","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine N.","family":"Marti","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki V.","family":"Georgiopoulou","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory University, Atlanta, 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