{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:16:20Z","timestamp":1790813780587,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2013,11,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Hemorrhagic risk assessment is a crucial issue in patients with nonvalvular atrial fibrillation (\n                      <jats:styled-content style=\"fixed-case\">NVAF<\/jats:styled-content>\n                      ) who are receiving oral anticoagulant therapy (\n                      <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content>\n                      ). Our aim was to analyze the relationship between vitamin E, which possesses anticoagulant properties, and bleeding events in\n                      <jats:styled-content style=\"fixed-case\">NVAF<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In this retrospective observational study we analyzed baseline serum cholesterol\u2010adjusted vitamin E (vit E\/chol) levels in 566 consecutive patients (59% males, mean age 73.6\u00a0years) receiving\n                      <jats:styled-content style=\"fixed-case\">OAT<\/jats:styled-content>\n                      followed up for a mean time of 22\u00a0months. Mean time in therapeutic\n                      <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n                      range (\n                      <jats:styled-content style=\"fixed-case\">TTR<\/jats:styled-content>\n                      ) was 64%. The overall incidence rate of any bleeding event was 9.2\/100\u00a0person\u2010years. Compared to patients who did not bleed, those who experienced bleeding events (n=92, 73 minor and 15 major bleedings and 4 cerebral hemorrhages according to International Society on Thrombosis and Haemostasis [\n                      <jats:styled-content style=\"fixed-case\">ISTH<\/jats:styled-content>\n                      ] ) classification) showed a significant difference for history of coronary heart disease (\n                      <jats:italic>P<\/jats:italic>\n                      =0.039),\n                      <jats:styled-content style=\"fixed-case\">HAS<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">BLED<\/jats:styled-content>\n                      score (\n                      <jats:italic>P<\/jats:italic>\n                      =0.002), and vit E\/chol levels (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Higher vit E\/chol serum levels were found in patients who bled compared to those who did not (5.27\u00b11.93 versus 4.48\u00b11.97\u00a0\u03bcmol\/cholesterol;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), with a progressive increase from minor (5.16\u00b11.91\u00a0\u03bcmol\/mmol cholesterol,\n                      <jats:italic>P<\/jats:italic>\n                      =0.006) to major bleedings (5.72\u00b12.0\u00a0\u03bcmol\/mmol cholesterol,\n                      <jats:italic>P<\/jats:italic>\n                      =0.008). A Cox proportional hazard model demonstrated that serum vit E\/chol quartiles (global\n                      <jats:italic>P<\/jats:italic>\n                      =0.0189) and\n                      <jats:styled-content style=\"fixed-case\">HAS<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">BLED<\/jats:styled-content>\n                      scores (\n                      <jats:italic>P<\/jats:italic>\n                      =0.005) predicted bleeding events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In a\n                      <jats:styled-content style=\"fixed-case\">NVAF<\/jats:styled-content>\n                      population being treated with warfarin, serum vitamin E predicted hemorrhagic events. Further study is necessary to see if the relationship between serum levels of vitamin E and bleeding is still maintained with the use of new anticoagulants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n                      : ClinicalTrials.gov. Unique identifier\n                      <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                      01882114.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.113.000364","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:01:50Z","timestamp":1383001310000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Vitamin E Serum Levels and Bleeding Risk in Patients Receiving Oral Anticoagulant Therapy: a Retrospective Cohort Study"],"prefix":"10.1161","volume":"2","author":[{"given":"Daniele","family":"Pastori","sequence":"first","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cangemi","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Saliola","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nocella","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bartimoccia","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommasa","family":"Vicario","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Farcomeni","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pignatelli","sequence":"additional","affiliation":[{"name":"Center of Atherothrombosis, I Medical Clinic, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Umberto I Policlinico of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-10-0690"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.10.002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.8.1471"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.8.880"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.04.017"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022913"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01109-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.04.142."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90866-1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03539-X"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.15.1610"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07072-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.1.56"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.1.230"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.600"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420302"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-1-200501040-00110"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.1.143"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00123.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.18.8171"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.6.1798.406k22_1798_1808"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.9.2945.409k29_2945_2950"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.10.2542"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00444.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.074"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192064"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0134"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651587"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602004"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.10.2143"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02345-X"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/107602960601200204"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.10.2434"},{"key":"e_1_3_3_42_2","first-page":"420","article-title":"Vitamin E potentiates the antiplatelet activity of aspirin in collagen\u2010stimulated platelets","volume":"87","author":"Celestini A","year":"2002","unstructured":"Celestini A, Pulcinelli FM, Pignatelli P, Lenti L, Frati G, Gazzaniga PP, Violi F. Vitamin E potentiates the antiplatelet activity of aspirin in collagen\u2010stimulated platelets. Haematologica. 2002;87:420\u2013426.","journal-title":"Haematologica"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c5702"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.113.000364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:00:19Z","timestamp":1715580019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.113.000364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11,18]]}},"alternative-id":["10.1161\/JAHA.113.000364"],"URL":"https:\/\/doi.org\/10.1161\/jaha.113.000364","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]},"assertion":[{"value":"2013-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e000364"}}