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Although a number of studies have measured\n              <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n              in breast cancer patients, there is currently limited data regarding expected\n              <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n              values in this patient population. Given that\n              <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n              is a poor prognostic sign and recently highlighted as a key measure to standardize by the\n              <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n              merican\n              <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n              eart\n              <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n              ssociation, we sought to review the available literature on\n              <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n              among breast cancer patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We identified 27 clinical trials and observational studies measuring\n              <jats:sc>vo<\/jats:sc>\n              <jats:sub>2max<\/jats:sub>\n              in the pre\u2013 and post\u2013adjuvant treatment setting for breast cancer. We compared\n              <jats:sc>vo<\/jats:sc>\n              <jats:sub>2max<\/jats:sub>\n              before to\n              <jats:sc>vo<\/jats:sc>\n              <jats:sub>2max<\/jats:sub>\n              after adjuvant therapy and compared\n              <jats:sc>vo<\/jats:sc>\n              <jats:sub>2max<\/jats:sub>\n              in female breast cancer patients with\n              <jats:sc>vo<\/jats:sc>\n              <jats:sub>2max<\/jats:sub>\n              in healthy controls.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We found that\n              <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n              was substantially lower in women with a history of breast cancer compared with healthy women and this was most pronounced among breast cancer patients in the post\u2010adjuvant setting. We conclude that knowledge of normative\n              <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n              values is critical to tailor appropriately timed exercise interventions in breast cancer patients susceptible to low\n              <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n              and subsequent cardiovascular risk.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.113.000432","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T04:54:18Z","timestamp":1389675258000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":171,"title":["Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values"],"prefix":"10.1161","volume":"3","author":[{"given":"Amanda B.","family":"Peel","sequence":"first","affiliation":[{"name":"University of Vermont College of Medicine, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Dittus","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Vermont Cancer Center, University of Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan G.","family":"Lakoski","sequence":"additional","affiliation":[{"name":"University of Vermont College of Medicine, Burlington, VT"},{"name":"Division of Hematology\/Oncology, Vermont Cancer Center, University of Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0437"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051073"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12529-010-9076-y"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21149"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-10-1156"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0870"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2901"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-1-199607010-00008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90315-1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.3.447"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.789"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052306"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052122"},{"key":"e_1_3_2_15_2","volume-title":"Chapter 5: Principles of Exercise Testing and Interpretation","author":"Wasserman K","year":"2012","unstructured":"Wasserman K, Hansen JE, Sue DY, Stringer WW, Sietsema KE, Sun XG, Whipp B. 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