{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:13:24Z","timestamp":1781550804757,"version":"3.54.5"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2014,1,27]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Development of thoracic aortic aneurysms is the most significant clinical phenotype in patients with Marfan syndrome. An inflammatory response has been described in advanced stages of the disease. Because the hallmark of vascular inflammation is local interleukin\u20106 (IL\u20106) secretion, we explored the role of this proinflammatory cytokine in the formation of aortic aneurysms and rupture in hypomorphic fibrillin\u2010deficient mice (mgR\/mgR).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              MgR\/mgR mice developed ascending aortic aneurysms with significant dilation of the ascending aorta by 12\u00a0weeks (2.7\u00b10.1 and 1.3\u00b10.1 for mgR\/mgR versus wild\u2010type mice, respectively;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). IL\u20106 signaling was increased in mgR\/mgR aortas measured by increases in IL\u20106 and SOCS3 mRNA transcripts (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and in cytokine secretion of IL\u20106, MCP\u20101, and GM\u2010CSF (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). To investigate the role of IL\u20106 signaling, we generated mgR homozygous mice with IL\u20106 deficiency (DKO). The extracellular matrix of mgR\/mgR mice showed significant disruption of elastin and the presence of dysregulated collagen deposition in the medial\u2010adventitial border by second harmonic generation multiphoton autofluorescence microscopy. DKO mice exhibited less elastin and collagen degeneration than mgR\/mgR mice, which was associated with decreased activity of matrix metalloproteinase\u20109 and had significantly reduced aortic dilation (1.0\u00b10.1 versus 1.6\u00b10.2\u00a0mm change from baseline, DKO versus mgR\/mgR,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) that did not affect rupture and survival.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">Activation of IL\u20106\u2010STAT3 signaling contributes to aneurysmal dilation in mgR\/mgR mice through increased MMP\u20109 activity, aggravating extracellular matrix degradation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.113.000476","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T03:48:39Z","timestamp":1390362519000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["IL\u20106 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin\u20101 Hypomorphic mgR\/mgR Mouse Model of Severe Marfan Syndrome"],"prefix":"10.1161","volume":"3","author":[{"given":"Xiaoxi","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talha","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, 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